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Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: The Healthy Twin Study

Cited 11 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Kayoung; Sung, Joohon; Lee, Sang Cheol; Park, Seung Woo; Kim, Youn Sic; Lee, Joo Yeon; Ebrahim, Shah; Song, Yun-Mi
Issue Date
2012-10
Publisher
Wiley
Citation
Preventive Cardiology, Vol.19 No.5, pp. 1161-1172
Keywords
의약학Atherosclerosiscarotid intima-medial thicknessgenetic variationrisk factor
Abstract
Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickness.Design: Cross-sectional observational study. Methods: A total of 706 Korean adults was selected from the Healthy Twin Study. The intima-media thickness of common, carotid bifurcation, and internal carotid artery were measured using B-mode ultrasound. Behavioral and biological cardiovascular risk factors were measured. Quantitative genetic and linear mixed analyses were performed to examine inherited and environmental contributions to intima-media thickness variation. Results: Heritability of intima-media thickness was moderately high with estimates (95% confidence intervals) of 0.48 (0.37, 0.59), 0.38(0.27, 0.49), and 0.45(0.34, 0.55) for common, carotid bifurcation, and internal carotid artery, respectively. The additive genetic cross-trait correlations between the segments ranged between 0.43 and 0.75, suggesting a shared genetic influence on the three carotid segments. Additive inherited effects contributed 21% and 31% (common and internal carotid, respectively) to the total variance of the intima-media thickness, while measured cardiovascular risk factors accounted for 46% and 26% (common and internal carotid, respectively). The cardiovascular risk factors significantly associated with carotid intima-media thickness were as follows: in men, alcohol use (bifurcation); physical activity (common and internal); BMI (all segments); diabetes (bifurcation and internal); hypertension (internal); and HDL-cholesterol (common and bifurcation); and in women, smoking (bifurcation), hypertension (common), total and LDL cholesterol (bifurcation and internal), and hs-CRP (common and internal). Conclusions: Individual cardiovascular risk factors were differentially associated with carotid intima-media thickness by segments and sex. Inherited effects made a heterogeneous contribution to intima-media thickness by segment. These findings may explain the differences in cardiovascular disease occurrence between men and women. ⓒ 2011 The European Society of Cardiology.
ISSN
1520-037X
Language
English
URI
http://hdl.handle.net/10371/94264
DOI
https://doi.org/10.1177/1741826711422763
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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