Publications
Detailed Information
Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: The Healthy Twin Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kayoung | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Lee, Sang Cheol | - |
dc.contributor.author | Park, Seung Woo | - |
dc.contributor.author | Kim, Youn Sic | - |
dc.contributor.author | Lee, Joo Yeon | - |
dc.contributor.author | Ebrahim, Shah | - |
dc.contributor.author | Song, Yun-Mi | - |
dc.creator | 성주헌 | - |
dc.date.accessioned | 2015-05-27T06:55:51Z | - |
dc.date.available | 2015-05-27T06:55:51Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | Preventive Cardiology, Vol.19 No.5, pp. 1161-1172 | - |
dc.identifier.issn | 1520-037X | - |
dc.identifier.uri | https://hdl.handle.net/10371/94264 | - |
dc.description.abstract | Background: Increased carotid intima-media thickness is associated with higher cardiovascular disease risk. This study aimed to evaluate the contributions of cardiovascular risk factors and inheritance to segment-specific carotid intima-media thickness.Design: Cross-sectional observational study. Methods: A total of 706 Korean adults was selected from the Healthy Twin Study. The intima-media thickness of common, carotid bifurcation, and internal carotid artery were measured using B-mode ultrasound. Behavioral and biological cardiovascular risk factors were measured. Quantitative genetic and linear mixed analyses were performed to examine inherited and environmental contributions to intima-media thickness variation. Results: Heritability of intima-media thickness was moderately high with estimates (95% confidence intervals) of 0.48 (0.37, 0.59), 0.38(0.27, 0.49), and 0.45(0.34, 0.55) for common, carotid bifurcation, and internal carotid artery, respectively. The additive genetic cross-trait correlations between the segments ranged between 0.43 and 0.75, suggesting a shared genetic influence on the three carotid segments. Additive inherited effects contributed 21% and 31% (common and internal carotid, respectively) to the total variance of the intima-media thickness, while measured cardiovascular risk factors accounted for 46% and 26% (common and internal carotid, respectively). The cardiovascular risk factors significantly associated with carotid intima-media thickness were as follows: in men, alcohol use (bifurcation); physical activity (common and internal); BMI (all segments); diabetes (bifurcation and internal); hypertension (internal); and HDL-cholesterol (common and bifurcation); and in women, smoking (bifurcation), hypertension (common), total and LDL cholesterol (bifurcation and internal), and hs-CRP (common and internal). Conclusions: Individual cardiovascular risk factors were differentially associated with carotid intima-media thickness by segments and sex. Inherited effects made a heterogeneous contribution to intima-media thickness by segment. These findings may explain the differences in cardiovascular disease occurrence between men and women. ⓒ 2011 The European Society of Cardiology. | en |
dc.language.iso | en | en |
dc.publisher | Wiley | en |
dc.subject | 의약학 | en |
dc.subject | Atherosclerosis | - |
dc.subject | carotid intima-medial thickness | - |
dc.subject | genetic variation | - |
dc.subject | risk factor | - |
dc.title | Segment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: The Healthy Twin Study | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이가영 | - |
dc.contributor.AlternativeAuthor | 성주헌 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 박승우 | - |
dc.contributor.AlternativeAuthor | 김연식 | - |
dc.contributor.AlternativeAuthor | 이주연 | - |
dc.contributor.AlternativeAuthor | 송윤미 | - |
dc.identifier.doi | 10.1177/1741826711422763 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000040632/17 | - |
dc.description.srnd | SEQ:17 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000040632 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077602 | - |
dc.description.srnd | DEPT_CD:902 | - |
dc.description.srnd | CITE_RATE:0 | - |
dc.description.srnd | FILENAME:12.segment-specific carotid intima-media_twins_cnv.pdf | - |
dc.description.srnd | DEPT_NM:보건학과 | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000040632/17 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.