혈장 수소이온 농도와 심장박출량
Cardiac Output During the Metabolic Acid-Base Disturbance in the Rabbit

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이재성; 김우겸
Issue Date
서울대학교 의과대학
Seoul J Med 1975;16(3):193-200
Cardiac output and hemodynamics were determ i n e d in the rabbit during the acute acid-base disturbance of metabolic origin by the intravenousi n fu si o n of 0.3 N hydrochloric acid or 0.6 M/L
sodium bicarbonate solution. Cardiac output was measured analyzing the saline
dilution curve recorded on physiograph the extra•
ml/min/ aterial conductivity, using Stewart-Hamilton form•
(± ula.
Under each level of plasma hydrogen ion concen
tration , arterial blood pressure, heart rate, cardiac
index, stroke volume and total peripheral resistance
were measured and relation of them were analyzed
1 . Normal cardiac index measured by saline cond
uctivity method in the rabbit was 72 C±5. 0) mJ!
min/kg. After the infusion of hydrochloric acid,
associated with the decrease of pH from 7.40 of
normal to 7.23 , cardiac index decreased to 50'
0.72 (±4.3) ml/min/kg. During metabolic acidosis,
th e higher the concentration of hydrogen ion ,
the more significantly decreased the cardiac
dex. After the infusion of sodium bicarbonate,
however, associated with the increase of pH from
7.40 to 7.51. cardiac output did not change
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 16 No.3 (1975)
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