혈장 수소이온 농도와 심장박출량

Abstract

Cardiac output and hemodynamics were determ i n e d in the rabbit during the acute acid-base disturbance of metabolic origin by the intravenousi n fu si o n of 0.3 N hydrochloric acid or 0.6 M/L sodium bicarbonate solution. Cardiac output was measured analyzing the saline dilution curve recorded on physiograph the extra• ml/min/ aterial conductivity, using Stewart-Hamilton form• (± ula. Under each level of plasma hydrogen ion concen tration , arterial blood pressure, heart rate, cardiac index, stroke volume and total peripheral resistance were measured and relation of them were analyzed 1 . Normal cardiac index measured by saline cond uctivity method in the rabbit was 72 C±5. 0) mJ! min/kg. After the infusion of hydrochloric acid, associated with the decrease of pH from 7.40 of normal to 7.23 , cardiac index decreased to 50' 0.72 (±4.3) ml/min/kg. During metabolic acidosis, th e higher the concentration of hydrogen ion , the more significantly decreased the cardiac dex. After the infusion of sodium bicarbonate, however, associated with the increase of pH from 7.40 to 7.51. cardiac output did not change significantly.