공급자항원을 이용한 백서신장이식의 면역반응과 능동적증강

Abstract

Immunological modification of immune res ponse in the organ recipient by either active or passive enhancement has been experiment ally showing a promise as a means of specific biological immuno-suppression by Wilson et al씨 15) and others. How-ever, precise method of administration of antigen or specific antibody is necessary. Active enhan-cement of rat renal allograft survival by pretreatment with 0.5 mg per kg of body weight donor specific soluble LBNF1 splenic antigen has achieved in Lewis recipient receiving LBNF1 kidney. Renal transplantation waS performed between Lewis inbred rats and LewisXBrown Norway F1 hybrid. LBNF1 rats' kidneys were transplanted to adult male Lewis rats weighing 350-450gm. Immunological assay studies were performed to detect the mechanism of immune responsiveness in the actively enhanced, long-survived 5 renal allograft recipients (averag survial time is 64 days)