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필로카르핀 간질중첩증 뇌파의 비선형 특성
Nonlinear Dynamics of EEG in Pilocarpine-induced Status Epilepticus

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Authors
정기영; 김재문; 김태우; 박희동; 김동욱
Issue Date
2003-05
Publisher
대한신경과학회
Citation
대한신경과학회지 Vol.21 No.5, pp. 507-512
Keywords
의약학Pilocarpine-induced status epilepticusEEG stageNonlinear analysisDimension
Abstract
Pilocarpine-induced status epilepticus (SE) model shows stereotypic EEG changes and behavioral characteristics.
Although neuronal damages and therapeutic responses are also dependent on SE stages, the dynamical
aspect of underlying neuronal interaction according to the SE stages has not been studied. We applied nonlinear analysis
to the EEG recorded from pilocarpine-induced SE model to characterize nonlinear dynamics of different SE stage
and to correlate therapeutic response with correlation dimension (D2). Methods: Ten male Spraque-Dawley rats weighing
150-250g were used in this experiment. EEG was continuously recorded during SE and was classified into 6 stages
as follows: baseline (BS), transitional (TR), discrete seizure (DS), continuous ictal discharges (CID), early periodic
epileptiform discharges (EP), and late periodic epileptiform discharges (LP). High dose diazepam (20 mg/kg) was
injected at the LP stage. SEs of 5 rats (control group) was controlled by diazepam and those of the rest (failed group)
were failed to stop status epilepticus. Results: Mean D2 value decreased progressively with fluctuation and was significantly
different for SE stage (df=5, F=11.594, p=0.000). Independent t-test showed that the difference of D2 value
between the controlled and failed group was significant at CID (df=40, t=2.591, p=0.013) and LP stage (df=49, t=-
2.425, p=0.019). Conclusions: These results suggest that nonlinear dynamical change at the late half of SE stage is one
of the contributing factors determining therapeutic responsiveness in pilocarpine-induced SE model.
Language
Korean
URI
http://hdl.handle.net/10371/94726
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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