Sex-specific relationships between adiposity and anthropometric measures and carotid intima-media thickness in Koreans: The Healthy Twin Study

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Song, Y-M; Lee, K.; Sung, J.; Kim, Y.S.; Lee, J.Y.
Issue Date
European Journal of Clinical Nutrition, vol.66, pp. 39–46
sexatherosclerosiscarotid arteriesgenetic variationadipositytwins
Background/Objectives: Increased adiposity, shorter stature, shorter leg length and carotid intima-media thickening are
associated with cardiovascular (CV) disease. This study aimed to evaluate the sex-specific phenotypic and genetic associations
between adiposity and anthropometric measures and carotid intima-media thickness (IMT).
Subjects/Methods: We measured IMT at common carotid artery (CCA-IMT), carotid bifurcation and internal carotid artery
(ICA-IMT) using B-mode ultrasound, and adiposity and anthropometric measures, including body mass index (BMI), height, leg
length, waist circumference (WC), waist-to-hip ratio and percentage of body fat; we also assessed conventional CV risk factors
among 706 Korean adults from the Healthy Twin Study. The associations were analyzed using quantitative genetic and linear
mixed analyses.
Results: In linear mixed analyses, BMI and WC had independent associations with the IMT at CCA-IMT and ICA-IMT and
CCA-IMT, respectively, after adjusting for age and conventional CV risk factors in men. By comparison, in women, adiposity and
anthropometric measures were associated with carotid IMT only before adjusting for the covariates. In men, there were
significant genetic correlations between BMI and CCA-IMT (rG ¼ 0.32±0.11), BMI and ICA-IMT (rG ¼ 0.35±0.11) and WC and
ICA-IMT (rG ¼ 0.32±0.13) after adjusting for covariates, whereas in women the cross-trait genetic correlations were no longer
significant after adjusting for the covariates.
Conclusions: In this Korean twins and families, we found sex-specific associations between adiposity and anthropometric
measures and the IMT at each segment of the carotid artery, and BMI and WC in men can be indicators predicting carotid
intima-media thickening regardless of age and CV risk factors.
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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