Concanavalin A 및 방사선 조사 처리한 마우스의 면양적혈구에 대한 입양면역

Abstract

Mice treated with Con A, via the same route as that of immunization , one or two days prior to immunization with SRBC showed a significant suppres' sion of direct PFC response. This immunosuppressive effect could be reversed by using higher dose of antigen. Cotreatment of Can A-activated spleen cells suppressed primary or secondary PFC response of the irradiated mice adoptively transferred with normal or immunized spleen cells. Normal syngeneic recipient mice transferred with Con A-activated spleen cells showed a suppression of primary direct PFC response. Recipients transfered with Con A-activated thymocytes showed no effect on PFC response It is suggested that Con A induced immunosuppressian of T ·dependent humoral immune response in mice is at least partly due to the activation of a subpopulation of T cells, and that the effect is transferred to syngeneic normal mice with Can A-activated spleen cells.