항경제의 혈중농도와 부작용에 관한 연구

Abstract

In thc 139 epileptic patients attcnding the neurologic department of SNUH in last half year , appearances of the side effects of diphenylhydantoin (DPH) were observed in relation to its serum concentrations. They had taken DPH as only anticonvulsant. Among side effects of DPH, diplopia, nausea nystagmas were appeared at the serum conentration of 13~5I'g/ml and 18.0 I'g/ml respectively, which belong to the optimal therapeutic serum conentration of DPH. Other side effects, sueh as vomiting, ataxia , dysdiadochokinesis, dizziness and G- I disturhances were observed all over the 30pg/m!. There are no difference of sex in the relation to the dosage and serum conentration but , there shows the tendencies to take more drugs to maintain the optimal therapeutic serum concentratIOn as young the age group of patients. The related literature were briefly reviewed