S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 22 No.2 (1981)
Minimal lesion 신증후군에서의 혈청지질과 고지질단백혈증(hyperlipoproteinemia)
Hyperlipidemia and hyperlipoproteinemia in minimal lesion nephrotic syndrome
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.22 No.2, pp. 249-259
- Sera obtained from 37 hospitalized patients with
minimal lesion nephrotic syndrome which is confirmed
by kidney biopsy, were analyzed for serum albumin,
serum lipids. 24hr urine protein, creatinine clearance,
In 23 of the patients lipoproteins were analyzed.
The following results were obtained.
1. Serum phospholipid (PL) was increased whenevcr
serum total cholesterol (TC) was increased but
to a lesser degree. The ratio of TCjPL were greater
than normal with the greatest concentrations of TC
(Fig. 1). All of the lipids increased together but the
relationship between TC and TG (triglyceride) was
very irregular as may be seen in Fig. 2.
2. Concentrations of serum cholesterol, phospholipid
were related inversely to serum albumin levels (r=
-0.72, r=-0.66 respectively, Fig. 3 and 4). The
relationship between triglyceride and albumin was less
regular than that of the other lipids (Fig. 5).
3. No significant correlation between serum lipids
and the 24hr urine protein loss or Ccr was noted
4. Serum lipoprotein patterns were determined in
23 patients. Nineteen of the 23 nephrotic patients had
abnormal lipoprotein patterns. 65% of the hyperlipoproteinemias
were Fredrickson type nb(Table 4).
5. HDL-cholesterol levels were not lower than that
of the normal.
6. No significant correlationship between serum
lipids and the steroid response was noted.