정상 한국인 및 순환기질환에서의 혈청 과산화지질에 관한 연구

Abstract

Lipid pcroxidation in vivo has been identified as a basic deterioration reaction in c인llular mechanism of aging process. Because of the damaging effects of lipid peroxidation and of accumulation of its characteristic product, this reaction is emphasized as one of the most deteriorative reactions that results in damage to cellular components. Lipid peroxide has been suspected as they might play some role in the process of athersclerosis and vascular complications of cardi avascular discases. To assess the role and responses of lipid peroxide in cardiovascular disease , the author measured serum lipid peroxide level in 172 cases of normal adult Koreans and in patients with hypertension, coronary heart disease , acute myocardial infarction and acute stroke. The author measured lipid peroxide by fluorometry according to the method after Yagi , with the following conclusions. 1. The mean serum cholesterol level in normal adult Koreans with ideal body weight is 170.8±36 3mg%, influenced by ages but not by sex. 2. The mean serum lipid peroxide level in normal adult Koreans is 3. 11 土0 . 5 6 n mole MDA/ml, influeneed by ages but not by sex 3. The serum lipid peroxide level is not significantly elevated in patients with hypertension and stable coronary heart diseases , but the serum cholesterol and triglyceride levels in the patients are higher than the normal population. 4. During the course of acute myocardial infarction the serum lipid peroxide level is sharply elevated initially and lowered rapidly. The serum cbolesterol level is lowered slightly and recovered to initiallevel in two weeks and the serum triglyceride level is elevated slightly. 5. During the course of acute stroke syndrome the serum lipid peroxide level is sharply elevated initially and lowered rapidly. The serum cholesterol level is lowered slightly and serum triglyceride level is elevated during the initial two weeks 6. The serum lipid peroxide Ie、이 is not signifi· cantly correlated to the serum cholesterol level in health and in cardiovascular diseases