정상 한국인의 HLA 항원 분포에 관한 연구
Studies on the Distribution of HLA Antigens in Normal Koreans

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박명희; 김상인
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서울대학교 의과대학
Seoul J Med 1984;25(1):90-99
The distribution pattcrn of HLA-A,B,C antigens
was investigated in 105 normal healthy unrelated
Korean adults. The HLA-A, B, C typing was carried
out by the standard NIH technique , using trays
obtained from UCLA Tissue Typing Laboratory. Gene
frequencies were estimated from antigen frequencies
using the formula GF=I 、I f-二AI' and haplotype
frequencies and gametic associations between HLAAlB
and HLA-B/C loci were calculated according to
Mattiuz et a1
The data were analyzed and summarized as follows
l. In normal Korean population, most frequent
antigens for the HLA-A locus were A2 51. 4%,
Aw24 49.5% , Aw33 23.8% and All 15.2% and
for the HLA-B locus Bw51 22.9%, Bw62 21. 0%,
Bw44 18.1%, Bw61 13.3% and Bw54 13.3% and
for the HLA-C locus Cw3 49.5%, Cwl 37.1%
and Cw4 I I. 4% in decreasing order of frequency.
Antigens of very low frequeneies C1%~2%) were
AI. Aw23, A29, Aw34, B8, B37, Bw38 and
Bw63. HLA-A25, A28, Aw32, BI4, BI8, Bw41,
Bw42, Bw45, Bw46, Bw47, Bw49, Bw50,
Bw53. Bw56 and Bw57 antigens were absent.
Blank gene frequencies were rather low; HLA-A
locus 1. 7%, HLA-B locus 5.3%, HLC-C locus
2. These HLA antigen frequencies of the Korean
population were quite similar to the Japanese
population, but in the Korean population, frequeneies
of A3, Aw30, Aw33, BI3, B27 and Bw
58 were higher and those of A26 and Bw52 were
lower compared to the Japanese population.
3. The common haplotypes(per 10,000) in the Korean
population were A2 Bw5!(647) , Aw33 Bw44(616) ,
Bw54 Cw!(690) and Bw58 C、‘,3(589). Significant
positive gametic associations were noted for eight
haplotypes(p<O. 05); Aw24 Bw52, Aw31 Bw51,
Aw33 Bw44, Aw33 Bw58, Bw54 Cwl, BX Cwl,
Bw58 Cw3 and Bw62 Cw4.
4. Although some differences were noted , the haplotype
frequencies and the patterns of gametic
associations in the Korean population were more
or less similar to those of the Japanese population.
Further studies are needed to confirm the genetic
similarities and differences for the HLA antigen
system between these two ethnic populations
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.1 (1984)
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