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사람태아의 골수외 조혈에 대한 형태학적 관찰
Morphological observation on the extramedullary hematopoiesis of human fetuses

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Authors
서창인; 지제근
Issue Date
1984-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1984;25(2):117-126
Abstract
To investigate the extent and temporal regression
of extramedullary hemopoiesis during fetal life , morphological
observations on fetal liver , spleen, and thymus were made
Normal human embryos and fetuses were collected
and proved to be normal after autopsy. The embryos
were serially sectioned. Their age ranged from 4 weeks
to 42 weeks of gestations. To compare the findings in
postnatal life 6 cases of normal newborn infants were
also studied
In early embryos only primitive red cells originated
from extraembryonic source could be seen , but on
the 36th day of gestation definitive red cell could first
be seen. The liver appeared to be the major organ of
hematopoietic activty from late embryo through midfetal
period. In the 36th day embryo, macrophages
and erythroblast series started to appear and hematopoiesis
reached full level of activity from the 11th
to 20th week. Thereafter the hematopoiesis decreased
gradually to disappear completely by the time of
birth. In the liver the most hematopoietic cell were
erythroblastic series and the liver was the major
source of hematopoiesis during fetal period. And it
was thought to be responsible for the fact that the
relativc weight of liver of fetus was greater than
that of adult.
In spleen hematopoietic activity appeared first in
the 12th week of gestation. However, the degree of
erythropoiesis was minimal in the spleen, and the
lymphopoiesis was significantly greater than erythropoietic
activity. Therefore it seemed that the spleen
plays a minor role in hematopoiesis during fetal period.
In thymus lymphocyte appeared first in the 10th
week of gestation. Both erythropoiesis and graulocytopoiesis
were present in the interlobular septa of
the thymus. However, thedegree of hematopoiesis in
general was rather smal l.
Intramedullary hematopoies began first in the elaviele
at the 11th week of gestation
Language
Korean
URI
http://hdl.handle.net/10371/9555
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.2 (1984)
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