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Potential application of bacteriophage pVp-1: Agent combating Vibrio parahaemolyticus strains associated with acute hepatopancreaticnecrosis disease (AHPND) in shrimp

Cited 14 time in Web of Science Cited 18 time in Scopus
Authors
Jun, Jin Woo; Han, Jee Eun; Tang, Kathy F.J.; Lightner, Donald V.; Kim, Jaehoon; Seo, Sang Won; Park, Se Chang
Issue Date
2016
Publisher
Elsevier
Citation
Aquaculture, vol.457, pp. 100–103
Keywords
Acute hepatopancreatic necrosis disease(AHPND)Early mortality syndrome (EMS)Vibrio parahaemolyticusBacteriophagePhage therapy
Abstract
Acute hepatopancreatic necrosis disease (AHPND, also known as early mortality syndrome, EMS) caused by
Vibrio parahaemolyticus has resulted in severe marine shrimp mortality and significant economic losses in related
aquaculture throughout Southeast Asia and Central America. As no viable remedy has yet been reported, the
main objective of this study was to develop an effective bacteriophage (phage)-based method of controlling
AHPND/EMS. To determine the bacteriolytic activity of phage pVp-1 against V. parahaemolyticus strains causing
AHPND/EMS, its infectivity was tested on 22 strains isolated from geographically diverse regions (5 of the Asian
type and 17 of the Mexican type). This phage was able to infect 90.9% (20 strains among 22 strains) of the
AHPND/EMS-related V. parahaemolyticus strains used in this study, and demonstrated substantial bacteriolytic
activity against three strains known to be highly pathogenic. To the best of our knowledge, this is the first report
of a virulent phage infecting V. parahaemolyticus strains responsible for AHPND/EMS, and indicates the potential
utility of pVp-1 in phage therapy.
Language
English
URI
http://hdl.handle.net/10371/95654
DOI
https://doi.org/10.1016/j.aquaculture.2016.02.018
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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