뇌동맥류 수술시 Sodium Nitroprusside 정주효과에 관한 임상적 연구
Clinical Study on the Effects of Sodium Nitroprusside during Operation of Cerebral Aneurysm

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서울대학교 의과대학
Seoul J Med 1984;25(2):230-235
The effect of sodium nitroprusside(SNP) on arterial
blood gas analysis was studied in 15 patients of
intracerebral aneurysm with normal cardio'pulmonary
function under general anesthesia. Systolic arterial
pressure decreased (p<0.005) from I04±1O torr to
85±6 torr, wbereas heart rate increased from 80±12
beats/min. to 92±12 beats/min. Thirty minutes after
discontinuation of SNP, arterial pressure and heart
beat returned to 108±14 torr and 75±8 beats/min. ,
respectively which were the level of pre·administ·
ration of SNP. Arterial pH, PaCO,. PaO, and bicar'
bonate were 7. 41±0.10, 32±6 mmHg, 193±42 mmHg
and 21±1 mEq/1 before'administration of SNP, 7.41
±O.ll, 34±7 mmHg, 188±44 mmHg and 21±2
mEq/1 during administration of SNP, and 7.39±
0.09 , 33±6 mmHg, 193±57 mmHg and 20±3 mEq/
I in 30 minutes after dscontinuation of SNP. There
was no change of pH, PaCO" PaO, and bicarbonate
in levels of pre'administration, during administration
and after discontinuation of SNP.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.2 (1984)
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