한국에 있어서의 알레르기질환의 역학적, 면역학적, 임상적 동태

Abstract

The epidemiological, immunological, and clinical features were analized in allergic patients visiting the allergy clinic of Seoul National University Hos· pital during last 5 years. 75.9% of the patients had respiratory allergies, 10.1% had cutaneous allergies. 11. 2% had both respiratory and cutaneous allergies. and 2.8% had anaphylaxis or allergies of other organs. Classifying respiratory allergies into intrinsic and extrinsic allergies by disease history and skin reaction to inhalant allergens, the former constituted 49.6% and the latter 50.4% (perennial, 46.6%, seasonal, 3.8%) The mean age of the patients with extrinsic res~ piratory allergies was lower than that of those with intrinsic allergies especially in males. There were atopic family histories in 23.5% of total patients Serum total IgE levels were increased in 68% of patients with extrinsic respiratory allergies, in 39% of those with intrinsic respiratory allergies, and in 50% of those with cutaneous allergies The inhalant allergens showing the most frequent positive skin reaction were those of house dust mites and house dus t. Other common allergens included those of cockroach, hay dust , cat , etc. However skin reactions to some allergens were not correlated with disease histories. Allergies to pollens or molds did not exceed 3% of the causes of rhinitis or asthma. Food allergens such as buckwheat and pupa seemed unique in Korea. The air-borne pollen survey in Seoul area revealed that the tree season was from mid-March to late· June, the grass season from late-March to late·Octover, and the weed season from Mid·June to late-November. Immunotherapy has been performed in more than 600 patients with respiratory allergies. Besides sym ptornatic improvement, most patients became less sensitive in skin test to offending allergens. The skin test reactivity may be an objective parameter indio eating the efficacy of immunotherapy during the maintenance course