갑상선 기능변조가 성호르몬 결합단백에 미치는 영향
Effect of Thyroid Disorder on Binding Capacity of Plasma Sex Hormone Binding Globulin in Rabbits

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서울대학교 의과대학
Seoul J Med 1984;25(4):477-483
Carrying out thyroidectomy and administering trHodothyronine
CT.) suhsequently in adult male rabbits.
the effect on sex hormone binding globulin and plasma
testosterone activity were investigated. Experimental
animals were divided into two groups according to
the control plasma concentrations of testosterone. On
the 1st day thyroid glands were removed, then on
the 3rd and 5th days, T. (0.5mg/kg, body wI. ) were
administered intraperitoneally. Venous blood samples
were taken on the morning of the 1st, 3rd, 5th and
7th days. Plasma total testosterone concentration and
SHBG binding capacity were determined by radioimmunoassay
and Rosner’s ammonium sulfate precipitation
Followings are the results obtained:
L Control levels of plasma testosterone , SHBG
binding capacity and their ratio were 335. 2±137. 3ng/
100ml, 9.10 士O. 82~g/100ml , 106.7±43. 8, respeclively. 2. After removal of thyroid glands, plasma testosteron"
decreased, SHBG binding capacity increased,
therefore their ratio increased. In low testosterone
group !>lasma testosterone increased but not exceeded
the level in high testosterone group_
3. By T3 administration plasma testosterone increased
and SHBG binding capacity showed decreasing
tendency in both of the groups_
4. Further administration of T3 showed decreasing
tendency in testosterone concentration but increasing
tendency in SHBG binding capacity.
From the above results we concluded that the acute
changes in SHBG binding capacity during thyroid
disorder were not ascribed to the direct eκects of T,
but rather to the indirect effect through the changes
in steroid such as testosterone.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.4 (1984)
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