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Vitamin A, BCG 및 Butylated Hydroxytoluene(BHT)가 Urethane 유발 폐선종생성에 미치는 영향에 관한 실험병리학적 연구
An Experimental Study on Effects of Vitamin A, BCG and Butylated Hydroxytoluene(BHT) in Development of Urethane induced Pulmonary Adenoma of Mice

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Authors
김영철; 함의근
Issue Date
1984-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1984;25(4):484-500
Abstract
An experimental study on urethane induced pulmouary
adenoma was carried out to observe the inhibitory
or enhancing effects of vitamin A, BCG and
hutylated hydroxytoluene(BHT) in its developmen t.
Experimental animal (389 ICR mice, average 10gm)
were divided into 10 groups including control , tumor
inhibition and enhancement groups: control group
(urethane: lmg/gm body weight, 2 times/week, for
4 weeks, intraperitoneal) , tumor inhibition groups
(vitamin A: 150,000unit/kg diet, 2 times/weeks, by
gastric tube, BCG:l. 3 x 10' CFU, one time, subutaneous)
and tumor enhancement group(BHT: O. 25mg/gm body
weight, weekly, intraperitoneal)
The results were as follows
1) Measuring body weights and organ weights of
lung , significant differences were seen between
control and experimental groups at the 24th week
after urethane treatment. Compared as control. in
vitamin A treated groups the body weights were
significantly decreased, while the organ weights of
lung were markedly increased in urethane groups,
and were notably more increased in BHT and
urethane combined treatment group.
2) Pulmonary adenoma with visible size on naked
eye( 르 O. 5mm in diameter) was not observed
until the 12th week by urethane treatment. The
sizes and numbers of tumors were increased in
relation to duration of time
In the 24th week by urethane treatment the incidence
of pulmonary adenoma was 100% in all
experimental groups(single and combined treatment).
No significant effects of Vitamin A, BeG and
BHT were encountered on the incidence of pul
monary adenoma.
3) The inhibitory effect of BCG on the growth of
pulmonary adenoma was remarkably demonstrated,
while the effect of vitamin A was rather week
in degree. The additive effects of vitamin A and
BCG in tumor inhibition were not clearly demonstrated.
4) The enhancing effect of BHT on the growth of
pulmonary adenoma was not demonstrated
In conclusion, the effects of vitamin A, BCG and
BHT seem to be notably significant on the growth
and less significant on the incidence in the develop
ment of urethane induced pulmonary adenoma. The
inhibitory effect on the growth seems to be more
significant in BCG than in vitamin A. No additive
inhibitory effects of vitamin A and BeG and enhancing
effect of BHT are encountered on the growth of
pulmonary adenoma.
Language
Korean
URI
http://hdl.handle.net/10371/9602
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.4 (1984)
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