기무라병의 병리학적 연구

Abstract

Observations on seven cases of angiolymphoid hyperplasia with eosinophilia (Kimuras disease) are presented. The lesion occurred most frequently in the second decade of life with the mean age of 28. 7 years. The chief complaints were mass or swelling in the neck, submandibular area or cheek for the average period of 4 years. In 4 of 7 patients the lesions were multiple. The lesions range from O. 7~ Bern in diameter and in 5 of 7 patients they measured 3cm or more in diameter. Of the 6 men and 1 woman involved, 5 showed involvement of subcutaneous adipose tissue and 2 showed involvement of both dermis and subcutaneous adipose tissue. The lesion extended into adjacent skeletal muscle (2 cases) and salivary gland (4 cases). Apart from blood eosi nophilia there were no systemic manifestations. The characteristic histopathological features were mild to moderate vascular proliferation, moderate to marked lymphoid infiltration, moderate to heavy eosinophilic infiltration and lymphoid follicles with germinal centers. In the early lesion vascular proliferation was prominent but in the later period lymphoid infiltration with lymphoid follicles was the main feature. All three cases recurred after excision of the lesion but in 1 of 2 cases the mass disappeared after admin istration of prednisone, suggesting benificial effect of prednisone These clinicopathologic features suggest that angiolymphoid hyperplasia with eosinophilia (Kimuras disease) is a distinct clinicopathological entity. Its clinicopathologic differences among different geographic areas and races and differential diagnoses are discussed