기무라병의 병리학적 연구
Angiolymphoid hyperplasia with eosinophilia (Kimura’s disease)

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서울대학교 의과대학
Seoul J Med 1984;25(4):501-510
Observations on seven cases of angiolymphoid hyperplasia
with eosinophilia (Kimura’s disease) are
presented. The lesion occurred most frequently in the
second decade of life with the mean age of 28. 7
years. The chief complaints were mass or swelling
in the neck, submandibular area or cheek for the
average period of 4 years. In 4 of 7 patients the
lesions were multiple. The lesions range from O. 7~
Bern in diameter and in 5 of 7 patients they measured
3cm or more in diameter. Of the 6 men and 1
woman involved, 5 showed involvement of subcutaneous
adipose tissue and 2 showed involvement of
both dermis and subcutaneous adipose tissue. The
lesion extended into adjacent skeletal muscle (2 cases)
and salivary gland (4 cases). Apart from blood eosi
nophilia there were no systemic manifestations. The
characteristic histopathological features were mild to
moderate vascular proliferation, moderate to marked
lymphoid infiltration, moderate to heavy eosinophilic
infiltration and lymphoid follicles with germinal
centers. In the early lesion vascular proliferation was
prominent but in the later period lymphoid infiltration
with lymphoid follicles was the main feature.
All three cases recurred after excision of the lesion
but in 1 of 2 cases the mass disappeared after admin
istration of prednisone, suggesting benificial effect of
These clinicopathologic features suggest that angiolymphoid
hyperplasia with eosinophilia (Kimura’s
disease) is a distinct clinicopathological entity. Its
clinicopathologic differences among different geographic
areas and races and differential diagnoses are discussed
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.4 (1984)
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