흰쥐 및 토끼의 실험적 아니사키스증
Experimental Anisakiasis in Albino Rats and Rabbits

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최원진; 김진복
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서울대학교 의과대학
흰쥐 및 토끼의 실험적 아니사키스증
the pathogenic process and pathology due to Anisakis
(type I) larvae infection in albino rats and rabbits.
The larvae were collected from two kinds of marine
fish, Pseudosciaena manchurica and Theragra chalco gramma , caught from the sea near the Korea Penin
sula. They were artificially fed to a total of 36 rats
and 20 rabbits and their migration pattern from
gastrointestinal tract to other organs and distribution
in host body as well as gross and microscopic changes
in tissues were observed.
The results obtained are as follows:
1. As early as 1 hour after infection in rats one
larva was found to have penetrated into stomach wall
and after 2 hours the larvae were also found from
omentum. After 4~8 hours many larvae escaped
from the gut and detected from abdominal cavity ,
abdominal wall and even liver parenchyme. The les
ion in stomach wall was characterized by destruction
of mucosal layer and extensive bleeding in areas
adjacent to larvae
2. After 1 or 3 days in rabbits many larvae were
found from stomach with their head portions embed·
ded into the wall and one larva was detected from
omentum. Several larvae were also found from inte'
stinal wall , abdominal cavity and abdominal wall after
5 days. The larvae found from stomach wall after
7 days were entirely embedded in the wall and
were moving transversely between submucosa and
muscle layer causing profuse hemorrhage there. Bl ee·
ding from stomach wall was more severe during
1~5 days after infection in rabbits. The lesion in
stomach and abdominal walls was characterized by
eosinophilic granuloma.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.4 (1984)
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