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Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy

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dc.contributor.authorLee, Kyung-Hun-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorOh, Do-Youn-
dc.contributor.authorLee, Se-Hoon-
dc.contributor.authorChie, Eui Kyu-
dc.contributor.authorHan, Wonshik-
dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorPark, In Ae-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorHeo, Dae Seog-
dc.contributor.authorHa, Sung Whan-
dc.contributor.authorBang, Yung-Jue-
dc.date.accessioned2009-09-22T13:19:34Z-
dc.date.available2009-09-22T13:19:34Z-
dc.date.issued2007-04-14-
dc.identifier.citationBMC Cancer 2007, 12:63en
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/10371/9683-
dc.description.abstractBACKGROUND: Bcl-2 is positively regulated by hormonal receptor pathways in breast cancer. A study was conducted to assess the prognostic significances of clinico-pathologic variables and of ER, PR, p53, c-erbB2, bcl-2, or Ki-67 as markers of relapse in breast cancer patients who had received the identical adjuvant therapy at a single institution. METHODS: A cohort of 151 curatively resected stage III breast cancer patients (M:F = 3:148, median age 46 years) who had 4 or more positive lymph nodes and received doxorubicin and cyclophosphamide followed by paclitaxel (AC/T) as adjuvant chemotherapy was analyzed for clinico-pathologic characteristics including disease-free survival (DFS) and overall survival (OS). Patients with positive ER and/or PR expression received 5 years of tamoxifen following AC/T. The protein expressions of biomarkers were assessed immunohistochemically. RESULTS: The median follow-up duration was 36 months, and 37 patients (24.5%) experienced a recurrence. Univariate analyses indicated that the tumor size (P = 0.038) and the number of involved lymph nodes (P < 0.001) significantly affected the recurrences. However, the type of surgery, the histology, histologic grade, the presence of endolymphatic emboli, and a close resection margin did not. Moreover, ER positivity (P = 0.013), bcl-2 positivity (P = 0.002) and low p53 expression (P = 0.032) were found to be significantly associated with a prolonged DFS. Furthermore, multivariate analysis identified 10 or more involved lymph nodes (HR 7.366; P < 0.001), negative bcl-2 expression (HR 2.895; P = 0.030), and c-erbB2 over-expression (HR 3.535; P = 0.001) as independent indicators of poorer DFS. In addition, bcl-2 expression was found to be significantly correlated with the expressions of ER and PR, and inversely correlated with the expressions of p53, c-erbB2 and Ki-67. Patients with bcl-2 expression had a significantly longer DFS than those without, even in the ER (+) subgroup. Moreover, OS was significantly affected by ER, bcl-2 and c-erbB2. CONCLUSION: Bcl-2 is an independent prognostic factor of DFS in curatively resected stage III breast cancer patients and appears to be a useful prognostic factor in combination with c-erbB2 and the number of involved lymph nodes.en
dc.description.sponsorshipThis study was supported by a Korean Research Foundation Grant funded by
the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-
2006-531-E00034) and by a grant from the Korean Health 21 R&D Project,
Ministry of Heath & Welfare, Republic of Korea (0412-CR01-0704-0001).
We also thank Julian Kanfer, English editor of BioMed Proofreading for her
assistance.
en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.titlePrognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapyen
dc.typeArticleen
dc.contributor.AlternativeAuthor이경훈-
dc.contributor.AlternativeAuthor임석아-
dc.contributor.AlternativeAuthor오도연-
dc.contributor.AlternativeAuthor이세훈-
dc.contributor.AlternativeAuthor지의규-
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor김동완-
dc.contributor.AlternativeAuthor김태유-
dc.contributor.AlternativeAuthor박인애-
dc.contributor.AlternativeAuthor노동영-
dc.contributor.AlternativeAuthor허대석-
dc.contributor.AlternativeAuthor하성환-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1186/1471-2407-7-63-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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