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Nephrotic syndrome in a child after umbilical-cord-blood transplantation

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Authors
Lee, Joo Hoon; Kwon, Bo Sang; Ha, Il Soo; Cheong, Hae Il; Moon, Kyung Chul; Ahn, Hyo Seop; Choi, Yong
Issue Date
2006-06-22
Publisher
Springer Verlag
Citation
Pediatr Nephrol 21:1312-1317
Keywords
Nephrotic syndromeStem-cell transplantationChronic graft-versus-host disease
Abstract
We report a 12-year-old girl who developed nephrotic syndrome 6 months after umbilical-cord-blood transplantation (UCBT) for acute lymphoblastic leukemia (L2). In addition to nephrotic syndrome, she also showed autoimmune hemolytic anemia, thrombocytopenia and gastrointestinal symptoms. Since these symptoms were manifested during the course of tapering immunosuppressive agents, a diagnosis of chronic graft-versus-host disease (GVHD) was made. Findings from a kidney biopsy were compatible with minimal-change disease (MCD), and focal glomerular capillary thrombosis and mild tubular damage were also noted. She was treated with methylprednisolone pulse therapy followed by oral prednisolone. Proteinuria disappeared in 14 days. Gastrointestinal symptoms, anemia and thrombocytopenia were also corrected. This is a case report of nephrotic syndrome as a manifestation of chronic GVHD developed after stem-cell transplantation. A review of the cases reported in the literature is also made.
ISSN
0931-041X (print)
1432-198X (online)
Language
English
URI
http://hdl.handle.net/10371/9693
DOI
https://doi.org/10.1007/s00467-006-0171-x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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