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Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

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dc.contributor.authorChang, Keun-A-
dc.contributor.authorKim, Hye-Sun-
dc.contributor.authorHa, Tae-Young-
dc.contributor.authorHa, Ji-Won-
dc.contributor.authorShin, Ki Young-
dc.contributor.authorJeong, Yun Ha-
dc.contributor.authorLee, Jean-Pyo-
dc.contributor.authorPark, Cheol-Hyoung-
dc.contributor.authorKim, Seonghan-
dc.contributor.authorBaik, Tae-Kyoung-
dc.contributor.authorSuh, Yoo-Hun-
dc.date.accessioned2009-09-23T08:40:50Z-
dc.date.available2009-09-23T08:40:50Z-
dc.date.issued2006-05-18-
dc.identifier.citationMol. Cell. Biol. 26:4327-4338en
dc.identifier.issn0270-7306-
dc.identifier.urihttp://hdl.handle.net/10371/9696-
dc.description.abstractAmyloid precursor protein (APP) has eight potential phosphorylation sites in its cytoplasmic domain. Recently, it has demonstrated that the constitutive phosphorylation of APP at T668 (APP695 isoform numbering) was observed specifically in the brain. Neuron-specific phosphorylation of APP at T668 is thought to be important for neuronal functions of APP, although its exact physiological significance remains to be clarified. In this study, we show that the phosphorylation of the APP intracellular domain (AICD) at T668 is essential for its binding to Fe65 and its nuclear translocation and affects the resultant neurotoxicity, possibly mediated through the induction of glycogen synthase kinase 3beta and tau phosphorylation by enhancing the formation of a ternary complex with Fe65 and CP2 transcription factor. Taken together, these results suggest that the phosphorylation of AICD at T668 contributes to the neuronal degeneration in Alzheimer's disease (AD) by regulating its translocation into the nucleus and then affects neurodegeneration; therefore, the specific inhibitor of T668 phosphorylation might be the target of AD therapy.en
dc.description.sponsorshipThis work was financially supported by a National Creative Research
Initiative Grant (2003–2005) from MOST and in part by the BK21
Human Life Sciences project.
en
dc.language.isoen-
dc.publisherAmerican Society for Microbiologyen
dc.titlePhosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegenerationen
dc.typeArticleen
dc.contributor.AlternativeAuthor장근아-
dc.contributor.AlternativeAuthor김혜선-
dc.contributor.AlternativeAuthor하태영-
dc.contributor.AlternativeAuthor하지원-
dc.contributor.AlternativeAuthor신기영-
dc.contributor.AlternativeAuthor정윤하-
dc.contributor.AlternativeAuthor이진표-
dc.contributor.AlternativeAuthor박철형-
dc.contributor.AlternativeAuthor김성한-
dc.contributor.AlternativeAuthor백태경-
dc.contributor.AlternativeAuthor서유헌-
dc.identifier.doi10.1128/MCB.02393-05-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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