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Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer

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Authors
Kang, Sokbom; Kim, Jae Weon; Kang, Gyeong Hoon; Park, Noh Hyun; Song, Yong Sang; Kang, Soon Beom; Lee, Hyo Pyo
Issue Date
2004-11-17
Publisher
Elsevier
Citation
Gynecol Oncol 2005;96:173-80
Keywords
DNA methylationMethionine synthaseMethylene-tetrahydrofolate reductaseO6-methylguanine DNA methyltransferaseUterine cervical cancer
Abstract
OBJECTIVE: This study was conducted to explore the association between the CpG island hypermethylation of tumor-associated genes and the polymorphisms of methyl group metabolizing enzymes in uterine cervical cancer. METHODS: We analyzed CpG island hypermethylation in 15 genes (APC, CDH1, COX2, DAPK, FHIT, GSTP1, HLTF1, hMLH1, MGMT, p14, p16, RASSF1A, RUNX3, THBS1, and TIMP3) and its association with the methylene-tetrahydrofolate reductase (MTHFR) C677T and A1298C and the methionine synthase (MS) A2756G polymorphisms in 82 Korean women with uterine cervical cancer. RESULTS: All uterine cervical cancer samples had at least one gene methylated. The average number of methylated genes was lower in patients with the heterozygous genotype of MTHFR and MS than in those with the common homozygous genotype, although this difference was not significant. The MTHFR 677 CT genotype was significantly associated with the decreased promoter hypermethylation of O(6)-methylguanine DNA methyltransferase (MGMT) (OR = 0.22, 95% confidence interval (CI) 0.07-0.70, P = 0.011). However, the MTHFR C677T and A1298C and the MS A2756G polymorphisms were not associated with an increased risk of uterine cervical cancer. CONCLUSION: These findings suggest that there is a possible interaction between epigenetic and genetic factors in uterine cervical cancer.
ISSN
0090-8258
Language
English
URI
http://hdl.handle.net/10371/9697
DOI
https://doi.org/10.1016/j.ygyno.2004.09.031
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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