Publications
Detailed Information
IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Su Jin | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Park, Weon Seo | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.date.accessioned | 2009-09-24T23:59:55Z | - |
dc.date.available | 2009-09-24T23:59:55Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | J. Immunol. 177: 5258-5268 | en |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9804 | - |
dc.description.abstract | Hypersensitivity pneumonitis (HP) is mediated by Th1 immune response. NKT cells regulate immune responses by modulating the Th1/Th2 balance. Therefore, we postulated that NKT cells play a critical role in the development of the HP by modulating the Th1/Th2 response. To address this issue, we explored the functional roles of NKT cells in Saccharopolyspora rectivirgula (SR)-induced HP. In CD1d(-/-) mice, the HP was worse in terms of histological changes, hydroxyproline levels, the CD4:CD8 ratio in bronchoalveolar lavage fluid, and SR-specific immune responses than in control mice. CD1d(-/-) mice showed elevated IFN-gamma production in the lung during the HP, and this was produced mainly by Gr-1+ neutrophils. The blockade of IFN-gamma in CD1d(-/-) mice attenuated the HP, whereas the injection of rIFN-gamma aggravated it. Moreover, the depletion of Gr-1+ neutrophils reduced CD8+ T cell numbers in bronchoalveolar lavage fluid during the HP. The adoptive transfer of IL-4(-/-) mouse NKT cells did not attenuate the HP, whereas wild-type or IFN-gamma(-/-) mouse NKT cells suppressed the HP. In conclusion, NKT cells producing IL-4 play a protective role in SR-induced HP by suppressing IFN-gamma-producing neutrophils, which induce the activation and proliferation of CD8+ T cells in the lung. | en |
dc.description.sponsorship | This work was supported by Grant 03-2006-014 from the Seoul National University
Hospital Research Fund and the National Research Laboratory Program (Grant 2005- 01319), and National R & D Program. Ministry of Science and Technology, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.title | IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황수진 | - |
dc.contributor.AlternativeAuthor | 김상희 | - |
dc.contributor.AlternativeAuthor | 박원서 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.