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Idiopathic membranous nephropathy in children

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Authors
Lee, Beom Hee; Cho, Hee Yeon; Kang, Hee Gyung; Ha, Il Soo; Cheong, Hae Il; Moon, Kyung Chul; Lim, In Seok; Choi, Yong
Issue Date
2006-09-02
Publisher
Springer Verlag
Citation
Pediatr Nephrol 21:1707-1715
Keywords
Membranous nephropathy in childrenAsymptomatic proteinuriaNephrotic syndromeCorticosteroidCyclosporineRenal vein thrombosis
Abstract
Idiopathic membranous nephropathy (MN) is a rare cause of asymptomatic proteinuria (AP) or nephrotic syndrome (NS) in childhood. To improve our understanding of its clinical course, we retrospectively reviewed 19 cases of idiopathic MN seen in our hospital over a period of 28.5 years, i.e., from January 1977 to July 2005. Eight patients (39%) had AP and 11 (61%) presented with NS. All eight AP patients achieved remission, regardless of treatment modality. Oral corticosteroid was given to all 11 NS patients, but only three of them responded to corticosteroid. Of the eight steroid non-responders, three achieved remissions with the addition of cyclosporine, and the five who were not administered additional immunosuppressive drugs had persistent NS. At the latest evaluation, all six NS patients that achieved remission remained free of proteinuria and had a normal renal function. Moreover, two of the 5 steroid non-responders showed persistent nephrotic-range proteinuria but a stable renal function. The remaining three steroid non-responders progressed into chronic renal insufficiency, and this progression was preceded by renal vein thrombosis (RVT) in two of the three patients. Presentation with NS (P=0.045) and the development of RVT (P=0.010) were identified as poor prognostic factors.
ISSN
0931-041X (print)
1432-198X (online)
Language
English
URI
http://hdl.handle.net/10371/9805
DOI
https://doi.org/10.1007/s00467-006-0246-8
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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