SHERP

Lack of promotion of mammary, lung and skin tumorigenesis by 20 kHz triangular magnetic fields

Cited 0 time in webofscience Cited 1 time in scopus
Authors
Lee, Hae-June; Choi, Soo-Yong; Jang, Ja-June; Gimm, Youn-Myoung; Pack, Jeong-Ki; Choi, Hyung-Do; Kim, Nam; Lee, Yun-Sil
Issue Date
2007-05-09
Publisher
Wiley-Blackwell;
Bioelectromagnetics Society (BEMS)
Citation
Bioelectromagnetics 28:446-453
Keywords
mammarylungskintumor promoter20 kHzmurine modelmagnetic field
Abstract
In order to evaluate possible tumorigenic effects of a 20 kHz intermediate frequency triangular magnetic field (IF), a frequency emitted from TV and PC monitors at 6.25 microT rms, which is the regulated exposure limit of magnetic field for the public in Korea, mammary tumors were produced in female Sprague-Dawley rats by oral intubation of dimethylbenz(a)anthracene (DMBA), lung tumors in ICR mice by scapular region injection of benzo(a)pyrene (BP), and skin tumors in female ICR mice by topical application of DMBA and tetradecanoylphorbol ester (TPA). IF was applied 8 h/day for 14 weeks beginning the day after DMBA treatment for mammary tumor experiment, for 6 weeks after weaning for lung tumor, and for 20 weeks beginning 1 week after DMBA application for skin tumor experiment. For skin tumors, TPA was applied once a week for 19 weeks. Results showed no significant differences in tumor incidence, mean tumor number and volume, and histological patterns between IF magnetic-field exposed and sham control rats in the above three tumor models. Therefore, we conclude that within the limitation or number of animals and the experimental conditions, 20 kHz IF triangular magnetic field exposure of 6.25 microT does not appear to be a strong co-tumorigenic agent in the chosen murine mammary, lung and skin models.
ISSN
0197-8462
Language
English
URI
http://hdl.handle.net/10371/9932
DOI
https://doi.org/10.1002/bem.20320
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse