SHERP

Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers

Cited 0 time in webofscience Cited 24 time in scopus
Authors
Chang, Mee Soo; Lee, Hye Seung; Lee, Byung Lan; Kim, Young Tae; Lee, Jeong Sang; Kim, Woo Ho
Issue Date
2005-09-03
Publisher
Elsevier
Citation
Pathol. Res. Pract. 201 (2005) 417-425
Keywords
EsophagusSquamous cell carcinomaDysplasiaPrognosisProtein bcl-2
Abstract
The aim of the current study was to evaluate the protein expression involved in the progression from dysplasia to invasive esophageal squamous cell carcinomas and to analyze the prognostic value of markers. Immunohistochemistry was performed for cell cycle regulators [p53, p21, p27, p16, cyclin D1, Rb], apoptosis-related proteins [Fas, Fas-L, FADD, TRAIL, DR4, DR5, caspase-8, caspase-3, bcl-2, Bax], tumor suppressor proteins [beta-catenin, E-cadherin, FHIT, Smad 4, VHL, PTEN, KAI-1], and oncoproteins [c-myc, COX-2, EGFR]. Caspase-3, TRAIL, Fas-L, Fas, Smad 4, VHL, E-cadherin, and EGFR revealed significant differences between dysplasia and their corresponding invasive cancer portion in 25 cases. In a total of 118 cases of invasive cancer, proteins with frequent (> or = 60% of the cases) alterations were p53 (overexpression in 64% of SCCs), p27 (loss in 91%), p16 (loss in 81%), and FHIT (loss in 75%). Early clinical stage and bcl-2 immunopositivity were related to the survival rate of patients. In conclusion, caspase-3, TRAIL, Fas-L, Fas, Smad 4, VHL, E-cadherin, and EGFR may be involved in the progression from dysplasia to invasive esophageal SCCs. Clinical stage and bcl-2 are independent prognostic factors throughout the multivariate analysis.
ISSN
0344-0338
Language
English
URI
http://hdl.handle.net/10371/9942
DOI
https://doi.org/10.1016/j.prp.2005.04.005
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse