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Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Mee Soo | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Lee, Jeong Sang | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2009-09-28T09:12:40Z | - |
dc.date.available | 2009-09-28T09:12:40Z | - |
dc.date.issued | 2005-09-03 | - |
dc.identifier.citation | Pathol. Res. Pract. 201 (2005) 417-425 | en |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9942 | - |
dc.description.abstract | The aim of the current study was to evaluate the protein expression involved in the progression from dysplasia to invasive esophageal squamous cell carcinomas and to analyze the prognostic value of markers. Immunohistochemistry was performed for cell cycle regulators [p53, p21, p27, p16, cyclin D1, Rb], apoptosis-related proteins [Fas, Fas-L, FADD, TRAIL, DR4, DR5, caspase-8, caspase-3, bcl-2, Bax], tumor suppressor proteins [beta-catenin, E-cadherin, FHIT, Smad 4, VHL, PTEN, KAI-1], and oncoproteins [c-myc, COX-2, EGFR]. Caspase-3, TRAIL, Fas-L, Fas, Smad 4, VHL, E-cadherin, and EGFR revealed significant differences between dysplasia and their corresponding invasive cancer portion in 25 cases. In a total of 118 cases of invasive cancer, proteins with frequent (> or = 60% of the cases) alterations were p53 (overexpression in 64% of SCCs), p27 (loss in 91%), p16 (loss in 81%), and FHIT (loss in 75%). Early clinical stage and bcl-2 immunopositivity were related to the survival rate of patients. In conclusion, caspase-3, TRAIL, Fas-L, Fas, Smad 4, VHL, E-cadherin, and EGFR may be involved in the progression from dysplasia to invasive esophageal SCCs. Clinical stage and bcl-2 are independent prognostic factors throughout the multivariate analysis. | en |
dc.description.sponsorship | This work was supported by grant number FG-03-11-
02 of the 21C Frontier Functional Human Genome Project from the Ministry of Science & Technology of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Esophagus | en |
dc.subject | Squamous cell carcinoma | en |
dc.subject | Dysplasia | en |
dc.subject | Prognosis | en |
dc.subject | Protein bcl-2 | en |
dc.title | Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 장미수 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.contributor.AlternativeAuthor | 김영태 | - |
dc.contributor.AlternativeAuthor | 이정상 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.identifier.doi | 10.1016/j.prp.2005.04.005 | - |
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