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Effect of maternal passive autoimmunization against myostatin on growth performance in chickens

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors
Moon, Y.S.; Lee, H.G.; Yin, Y.H.; Jin, X.; Hong, Z.S.; Cho, J.S.; Kim, S.C.; You, S.K.; Jin, D.I.; Han, Jae Yong; Choi, Y.J.
Issue Date
2005
Publisher
The Asian-australasian Association of Animal
Citation
Asian-australasian Journal of Animal Sciences, vol.18 no.7, pp. 1017-1021
Keywords
MyostatinAutoimmunizationMuscleGrowthChicken
Abstract
Myostatin is a negative regulator of skeletal muscle growth and a loss of functional myostatin protein increases muscle hypertrophy and hyperplasia in cattle. The present study was conducted to investigate whether maternal passive immunization against myostatin would improve growth performance in chickens. A complete broiler myostatin cDNA was cloned and it was expressed into two transcripts as 1,128 bp and 985 bp by alternative splicing. A conjugated mature myostatin (350 bp) was used to induce autoimmunization and maternal passively immunized chickens was used for the experiment. It was confirmed that there was a maternal passive immunization against myostatin at zero weeks of age, but its effect was reduced by 6 weeks of age. The auto-immunized groups showed smaller body weights than those of control group during the growing period and the difference was getting bigger with time until 6 weeks of age. These results suggest that passive autoimmunization against myostatin used in this study is not potent enough to stimulate growth performance in chickens.
ISSN
1011-2367
Language
English
URI
https://hdl.handle.net/10371/100214
DOI
https://doi.org/10.5713/ajas.2005.1017
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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