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Identification and characterization of the peroxiredoxin gene family in chickens

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dc.contributor.authorHan, Jae Yong-
dc.contributor.authorSong, K.D.-
dc.contributor.authorShin, J.H.-
dc.contributor.authorHan, B.K.-
dc.contributor.authorPark, T.S.-
dc.contributor.authorPark, H.J.-
dc.contributor.authorKim, J.-K.-
dc.contributor.authorLillehoj, H.S.-
dc.contributor.authorLim, J.M.-
dc.contributor.authorKim, H.-
dc.date.accessioned2017-01-23T08:02:08Z-
dc.date.available2017-01-23T08:02:08Z-
dc.date.issued2005-
dc.identifier.citationPoultry Science Journal, vol.84 no.9, pp. 1432-1438ko_KR
dc.identifier.issn0032-5791-
dc.identifier.urihttps://hdl.handle.net/10371/100217-
dc.description.abstractPeroxiredoxin (PRX) is a crucial antioxidant protein that protects against endogenously produced peroxides in prokaryotes to eukaryotes. To date, 6 different isoforms have been identified in mammals. In this study, we describe the first members of the PRX protein family to be characterized in Chicken. Through bioinformatics analysis, we observed that at least 4 different classes of PRX protein have been evolutionarily conserved in chickens. Furthermore, in vitro functional assays of the candidate chicken PRX proteins demonstrated that they had levels of antioxidant activity similar to those of the mammalian enzymes. The expression patterns of the PRX transcript in several chicken tissues were not tissue specific, suggesting that they might play an essential role as a housekeeping gene in all tissues to protect against oxidative damage. In conclusion, the sequences of the putative members of this functional gene family in chickens could be effectively retrieved in silico through bioinformatics analysis, and the functionality of their gene products evaluated by in vitro comparative assay.ko_KR
dc.language.isoenko_KR
dc.publisherOxford University Pressko_KR
dc.subjectchickenko_KR
dc.subjectoxidative damageko_KR
dc.subjectantioxidant activityko_KR
dc.subjectperoxiredoxinko_KR
dc.titleIdentification and characterization of the peroxiredoxin gene family in chickensko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한재용-
dc.identifier.doi10.1093/ps/84.9.1432-
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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