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Cloning and functional characterization of chicken interleukin-17D
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Yeong Ho | - |
dc.contributor.author | Lillehoj, Hyun S. | - |
dc.contributor.author | Park, Dong Woon | - |
dc.contributor.author | Lee, Sung Hyen | - |
dc.contributor.author | Han, Jae Yong | - |
dc.contributor.author | Shin, Ji Hye | - |
dc.contributor.author | Park, Myeung Sun | - |
dc.contributor.author | Kim, Jin-Kyoo | - |
dc.date.accessioned | 2017-01-25T09:18:08Z | - |
dc.date.available | 2017-01-25T09:18:08Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Veterinary Immunology and Immunopathology, vol.126 no.1-2, pp. 1-8 | ko_KR |
dc.identifier.issn | 0165-2427 | - |
dc.identifier.uri | https://hdl.handle.net/10371/100262 | - |
dc.description.abstract | The chicken interleukin-17D was cloned from a testis cDNA library prepared from the Korean native chicken. The full-length
chicken IL-17D (chIL-17D) cDNA consisted of a 348 nucleotide sequence encoding an open reading frame of 116 amino acids with a predicted molecular mass of 13.3 kDa. Comparison of the deduced amino acid sequence of chIL-17D with homologous proteins from human, mouse and opossum revealed 64%, 53% and 76% identity, respectively, including six conserved cysteine residues present in the mammalian polypeptides. The chIL-17D gene transcript was expressed in a wide range of tissues, and highest levels were in pancreas, thymus and lung. Following Eimeria maxima infection, levels of the chIL-17D mRNA were up-regulated in the intestinal jejunum, bursa, lung, and spleen but decreased in the thymus. Infected chickens also expressed greater levels of chIL-17D mRNA in CD4+, CD8+ and TCR1+ intestinal intraepithelial lymphocytes while decreased expression was seen in TCR2+ cells. Treatment of CHCC-OU2 fibroblasts with chIL-17D recombinant protein induced the expression of IL-6 and IL-8. Collectively, these results suggest that chL-17D has structural and functional similarities to mammalian IL-17Ds and that it plays an important role in local gut innate immune responses during experimental coccidiosis. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Elsevier | ko_KR |
dc.subject | IL-17D | ko_KR |
dc.subject | Chicken | ko_KR |
dc.subject | Cytokine | ko_KR |
dc.subject | Local immune response | ko_KR |
dc.title | Cloning and functional characterization of chicken interleukin-17D | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍영호 | - |
dc.contributor.AlternativeAuthor | 박동운 | - |
dc.contributor.AlternativeAuthor | 이성현 | - |
dc.contributor.AlternativeAuthor | 한재용 | - |
dc.contributor.AlternativeAuthor | 신지혜 | - |
dc.contributor.AlternativeAuthor | 박명선 | - |
dc.contributor.AlternativeAuthor | 김진규 | - |
dc.identifier.doi | 10.1016/j.vetimm.2008.06.002 | - |
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