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Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Gwak, Geum-Youn | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Lee, Sung Hee | - |
dc.contributor.author | Jang, Ja June | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.date.accessioned | 2009-10-04T23:23:43Z | - |
dc.date.available | 2009-10-04T23:23:43Z | - |
dc.date.issued | 2006-02-21 | - |
dc.identifier.citation | Biochem. Biophys. Res. Commun. 342 (2006) 1108-1113. | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/10034 | - |
dc.description.abstract | In cholestatic liver diseases, bile acids induce hepatocyte apoptosis and thus cause liver injury, but hepatic stellate cells (HSCs) survive in the presence of bile acids. We attempted to analyze anti-apoptotic signaling pathways in HSCs against bile acid-induced apoptosis. In immortalized human HSCs and primarily cultured rat HSCs, bile acid treatment increased the expression levels of cyclooxygenase-2 (COX-2) and Mcl-1. COX-2 induction was found to be due to transcriptional enhancement dependent on p42/44, p38 MAPK, and JNK activation, whereas Mcl-1 induction resulted from bile acid-mediated protein stabilization in a Raf-1-dependent manner. Moreover, the inhibitions of either COX-2 activity by celecoxib or Mcl-1 induction by siRNA transfection rendered HSCs susceptible to bile acid-induced apoptosis. These results imply that the bile acid-mediated inductions of COX-2 and Mcl-1 may lead to HSC survival in cholestatic liver diseases. | en |
dc.language.iso | en | en |
dc.publisher | Academic Press | en |
dc.subject | Animals | en |
dc.subject | Apoptosis/drug effects/*physiology | en |
dc.subject | Cell Line | en |
dc.subject | Cell Survival/drug effects | en |
dc.subject | Chenodeoxycholic Acid/administration & dosage/*metabolism | en |
dc.subject | Cyclooxygenase 2/*metabolism | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Hepatocytes/drug effects/*metabolism | en |
dc.subject | Humans | en |
dc.subject | Neoplasm Proteins/*metabolism | en |
dc.subject | Proto-Oncogene Proteins c-bcl-2/*metabolism | en |
dc.subject | Rats | en |
dc.subject | Signal Transduction/drug effects/physiology | en |
dc.title | Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김강모 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 곽금윤 | - |
dc.contributor.AlternativeAuthor | 김원 | - |
dc.contributor.AlternativeAuthor | 이승희 | - |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.02.072 | - |
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