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Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells

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dc.contributor.authorKim, Kang Mo-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorGwak, Geum-Youn-
dc.contributor.authorKim, Won-
dc.contributor.authorLee, Sung Hee-
dc.contributor.authorJang, Ja June-
dc.contributor.authorLee, Hyo-Suk-
dc.date.accessioned2009-10-04T23:23:43Z-
dc.date.available2009-10-04T23:23:43Z-
dc.date.issued2006-02-21-
dc.identifier.citationBiochem. Biophys. Res. Commun. 342 (2006) 1108-1113.en
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10371/10034-
dc.description.abstractIn cholestatic liver diseases, bile acids induce hepatocyte apoptosis and thus cause liver injury, but hepatic stellate cells (HSCs) survive in the presence of bile acids. We attempted to analyze anti-apoptotic signaling pathways in HSCs against bile acid-induced apoptosis. In immortalized human HSCs and primarily cultured rat HSCs, bile acid treatment increased the expression levels of cyclooxygenase-2 (COX-2) and Mcl-1. COX-2 induction was found to be due to transcriptional enhancement dependent on p42/44, p38 MAPK, and JNK activation, whereas Mcl-1 induction resulted from bile acid-mediated protein stabilization in a Raf-1-dependent manner. Moreover, the inhibitions of either COX-2 activity by celecoxib or Mcl-1 induction by siRNA transfection rendered HSCs susceptible to bile acid-induced apoptosis. These results imply that the bile acid-mediated inductions of COX-2 and Mcl-1 may lead to HSC survival in cholestatic liver diseases.en
dc.language.isoenen
dc.publisherAcademic Pressen
dc.subjectAnimalsen
dc.subjectApoptosis/drug effects/*physiologyen
dc.subjectCell Lineen
dc.subjectCell Survival/drug effectsen
dc.subjectChenodeoxycholic Acid/administration & dosage/*metabolismen
dc.subjectCyclooxygenase 2/*metabolismen
dc.subjectDose-Response Relationship, Drugen
dc.subjectHepatocytes/drug effects/*metabolismen
dc.subjectHumansen
dc.subjectNeoplasm Proteins/*metabolismen
dc.subjectProto-Oncogene Proteins c-bcl-2/*metabolismen
dc.subjectRatsen
dc.subjectSignal Transduction/drug effects/physiologyen
dc.titleBile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김강모-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor곽금윤-
dc.contributor.AlternativeAuthor김원-
dc.contributor.AlternativeAuthor이승희-
dc.contributor.AlternativeAuthor장자준-
dc.contributor.AlternativeAuthor이효석-
dc.identifier.doi10.1016/j.bbrc.2006.02.072-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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