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Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Yoo-Ri | - |
dc.contributor.author | Park, Sung Wook | - |
dc.contributor.author | Choi, Shin-Young | - |
dc.contributor.author | Kim, Seung Woo | - |
dc.contributor.author | Moon, Ka Young | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Lee, Kihwang | - |
dc.date.accessioned | 2017-02-01T02:39:12Z | - |
dc.date.available | 2017-02-01T02:39:12Z | - |
dc.date.issued | 2017-01-07 | - |
dc.identifier.citation | Cardiovascular Diabetology, 16(1):4 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100355 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes. Methods The medical records of 110 patients with type 2 diabetes (70 statin users and 40 non-users) were retrospectively reviewed. The two outcome measures were progression of diabetic retinopathy by two or more steps on the early treatment diabetic retinopathy study scale and diabetic macular edema based on optical coherence tomography. Serum lipid profiles were analyzed from 6months prior to diagnosis of diabetic macular edema. Results Diabetic retinopathy progressed in 23% of statin users and 18% of non-users (p=0.506), but diabetic macular edema was present in 23% of statin users and 48% of non-users (p=0.008). Statins reduced low-density lipoprotein cholesterol levels in patients with and without diabetic macular edema (p=0.043 and p=0.031, respectively). Among statin users, patients with diabetic macular edema had higher levels of triglycerides (p=0.004) and lower levels of high-density lipoprotein cholesterol (p=0.033) than those without diabetic macular edema. Logistic regression analysis showed that statin use significantly lowered the risk of diabetic macular edema [odds ratio (OR): 0.33, 95% confidence interval (CI) 0.12–0.91, p=0.032]. Hypertriglyceridemia at 6months prior to development of macular edema was significantly associated with central retinal thickness (OR: 1.52; 95% CI 1.14–2.02, p=0.005). Conclusions Lipid lowering therapy with statins protected against the development of diabetic macular edema and progression of diabetic retinopathy in patients with type 2 diabetes. Hypertriglyceridemia could be used as a surrogate marker for diabetic macular edema. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Diabetic macular edema | ko_KR |
dc.subject | Diabetic retinopathy | ko_KR |
dc.subject | Statin | ko_KR |
dc.subject | Triglyceride | ko_KR |
dc.title | Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정유리 | - |
dc.contributor.AlternativeAuthor | 박성욱 | - |
dc.contributor.AlternativeAuthor | 최신영 | - |
dc.contributor.AlternativeAuthor | 김승우 | - |
dc.contributor.AlternativeAuthor | 문가영 | - |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 이기황 | - |
dc.identifier.doi | 10.1186/s12933-016-0486-2 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2017-01-08T03:02:49Z | - |
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