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Effect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgery

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dc.contributor.authorKim, Tae Kyong-
dc.contributor.authorCho, Youn Joung-
dc.contributor.authorLim, Chae-won-
dc.contributor.authorMin, Jeong Jin-
dc.contributor.authorChoi, Eue-Keun-
dc.contributor.authorHong, Deok Man-
dc.contributor.authorJeon, Yunseok-
dc.date.accessioned2017-02-06T02:31:51Z-
dc.date.available2017-02-06T02:31:51Z-
dc.date.issued2016-08-03-
dc.identifier.citationBMC Anesthesiology, 16(1):56ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100434-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
ko_KR
dc.description.abstractAbstract

Background
Ramosetron is a relatively new 5-hydroxytryptamine three receptor antagonist with higher binding affinity and more prolonged duration of action compared to ondansetron. The present study was performed to evaluate the effects of ramosetron on QTc interval and possible cardiovascular adverse effects in patients undergoing cardiac surgery.


Method
A total of 114 patients who underwent off-pump coronary artery bypass surgery were enrolled in this randomised placebo-controlled trial. Patients were allocated into two groups that received intravenous injection of 0.3 mg ramosetron or normal saline during induction of anaesthesia. QTc intervals were measured before the operation, intraoperatively (0, 1, 2, 3, 5, 10, 15, 30, 45, 60, 90, 120, and 240 min after injection of ramosetron or normal saline), at the end of the operation, and on postoperative day 1.


Results
There were no differences in mean QTc interval between groups at every time point. However, maximal change in QTc interval during surgery was higher in the ramosetron group than the placebo group (25.1 ± 22.0 vs. 17.5 ± 14.5 ms, 95 % CI 0.34–14.78, P = 0.040). Also, there were more patients with a QTc interval increase of > 60 ms in the ramosetron group (5 vs. 0, 95 % CI 1.6–18.0, P = 0.021). There were no significant differences in cardiovascular complications.


Conclusions
Ramosetron administered during induction of anaesthesia may affect maximal change in QTc interval during off-pump coronary artery bypass surgery. Ramosetron should be used with caution in high risk patients for developing Torsades de Pointes.


Trial registration
ClinicalTrials.gov NCT02139241. Registered November 12, 2013
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectCardiac surgeryko_KR
dc.subjectCorrected QT intervalko_KR
dc.subjectRamosetronko_KR
dc.subjectTorsadogenic actionko_KR
dc.subjectSerotonin 5-HT3 receptor antagonistsko_KR
dc.titleEffect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgeryko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김태경-
dc.contributor.AlternativeAuthor조윤정-
dc.contributor.AlternativeAuthor임채원-
dc.contributor.AlternativeAuthor민정진-
dc.contributor.AlternativeAuthor최의근-
dc.contributor.AlternativeAuthor홍덕만, ㅏ-
dc.contributor.AlternativeAuthor전윤석-
dc.identifier.doi10.1186/s12871-016-0222-1-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2017-01-06T09:59:39Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
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