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Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites
DC Field | Value | Language |
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dc.contributor.author | Jung, Hyo Young | - |
dc.contributor.author | Yoo, Dae Young | - |
dc.contributor.author | Kim, Woosuk | - |
dc.contributor.author | Nam, Sung Min | - |
dc.contributor.author | Kim, Jong Whi | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Kwak, Youn-Gil | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Hwang, In Koo | - |
dc.date.accessioned | 2017-02-06T04:21:27Z | - |
dc.date.available | 2017-02-06T04:21:27Z | - |
dc.date.issued | 2014-12-11 | - |
dc.identifier.citation | BMC Complementary and Alternative Medicine, 14(1):476 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100439 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ko_KR |
dc.description.abstract | Abstract
Background In this study, we investigate the effects of valerian root extracts (VE) on physical and psychological stress responses by utilizing a communication box. Methods Eight-week-old ICR mice received oral administration of VE (100mg/kg/0.5ml) or equal volume of distilled water in every day for 3weeks prior to being subjected to physical or psychological stress for 3days, which are induced by communication box developed for physical electric shock and psychological stress by nociceptive stimulation-evoked responses. The stress condition was assessed by forced swimming test and serum corticosterone levels. In addition, norepinephrine (NE), serotonin (5-HT), and their metabolites such as 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the hippocampus and amygdala at 1h after final stress condition, respectively. Results Immobility time and corticosterone levels were significantly increased in both the physical and psychological stress groups compared to the control group. The administration of VE significantly reduced these parameters in both the physical and psychological stress groups. In addition, compared to the control group, physical and psychological stress groups showed significantly increased levels of MHPG-SO4 and 5-HIAA in the hippocampus and amygdala, respectively. The administration of VE significantly suppressed the increase of MHPG-SO4 and 5-HIAA in the two stress groups. Conclusion These results suggest that VE can suppress physical and psychological stress responses by modulating the changes in 5-HT and NE turnover in the hippocampus and amygdala. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Valeriana officinalis | ko_KR |
dc.subject | Physical stress | ko_KR |
dc.subject | Psychological stress | ko_KR |
dc.subject | Serotonin | ko_KR |
dc.subject | Norepinephrine | ko_KR |
dc.subject | Hippocampus | ko_KR |
dc.subject | Amygdala | ko_KR |
dc.title | Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정효영 | - |
dc.contributor.AlternativeAuthor | 유대영 | - |
dc.contributor.AlternativeAuthor | 김우석 | - |
dc.contributor.AlternativeAuthor | 남성민 | - |
dc.contributor.AlternativeAuthor | 김종휘 | - |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 곽윤길 | - |
dc.contributor.AlternativeAuthor | 윤여성 | - |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.identifier.doi | 10.1186/1472-6882-14-476 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Jung et al.; licensee BioMed Central. | - |
dc.date.updated | 2017-01-06T10:00:33Z | - |
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