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Relationship between total phenolic contents and biological properties of propolis from 20 different regions in South Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Xue | - |
dc.contributor.author | Sankarapandian, Karuppasamy | - |
dc.contributor.author | Cheng, Yizhe | - |
dc.contributor.author | Woo, Soon Ok | - |
dc.contributor.author | Kwon, Hyung Wook | - |
dc.contributor.author | Perumalsamy, Haribalan | - |
dc.contributor.author | Ahn, Young-Joon | - |
dc.date.accessioned | 2017-02-06T04:37:14Z | - |
dc.date.available | 2017-02-06T04:37:14Z | - |
dc.date.issued | 2016-02-18 | - |
dc.identifier.citation | BMC Complementary and Alternative Medicine, 16(1):65 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100442 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Propolis (or bee glue), collected from botanical sources by honey bee, has been used as a popular natural remedies in folk medicine throughout the world. This study was conducted to assess growth inhibitory effects of ethanol extracts of propolis (EEPs) from 20 different regions in South Korea on human intestinal bacteria as well as their human β-amyloid precursor cleavage enzyme (BACE-1), acetylcholinesterase (AChE) inhibitory, antioxidant, antiproliferative, and anti-human rhinovirus activities. Methods The Bonferroni multiple-comparison method was used to test for significant differences in total polyphenol and flavonoid contents among EEP samples using SAS 9.13 program. Correlation coefficient (r) analysis of the biological activities of EEP samples was determined using their 50% inhibition concentration or minimal inhibitory concentration values and their polyphenol or flavonoid contents in 20 native Korean EEP samples. Results The amounts of total polyphenol and flavonoids in the Korean EEP samples ranged from 49 to 239mg gallic acid equivalent (GAE)/g EEP (Brazilian, Chinese, and Australian samples, 127–142mg GAE/g EEP) and from 21 to 50mg quercetin equivalent (QE)/g EEP (Brazilian, Chinese, and Australian samples, 33–53mg QE/g EEP), respectively. Correlation coefficient analysis showed that total polyphenol contents may be negatively correlated with 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (r = −0.872) and total flavonoid content has no correlation with the activity (r = 0.071). No direct correlation between BACE-1 inhibition, AChE inhibition, or antiproliferative activity and total polyphenol or total flavonoid content in Korean EEP samples was found. Gram-positive and Gram-negative bacteria were observed to have different degrees of antimicrobial susceptibility to the EEP samples examined, although ciprofloxacin susceptibility among the bacterial groups did not differ greatly. Conclusions Further studies will warrant possible applications of propolis as potential therapeutic BACE-1 blocker, antioxidant, antiproliferative agent, and antimicrobial agent. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Korean propolis | ko_KR |
dc.subject | BACE-1 | ko_KR |
dc.subject | Antioxidant | ko_KR |
dc.subject | Acetylcholinesterase inhibitory activity | ko_KR |
dc.subject | Antiproliferative | ko_KR |
dc.subject | Antibacterial activity | ko_KR |
dc.subject | Anti-human rhinovirus activity | ko_KR |
dc.subject | Polyphenol | ko_KR |
dc.subject | Flavonoid | ko_KR |
dc.subject | Correlation | ko_KR |
dc.title | Relationship between total phenolic contents and biological properties of propolis from 20 different regions in South Korea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 우순옥 | - |
dc.contributor.AlternativeAuthor | 권형욱 | - |
dc.contributor.AlternativeAuthor | 안영준 | - |
dc.identifier.doi | 10.1186/s12906-016-1043-y | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Wang et al. | - |
dc.date.updated | 2017-01-06T10:00:58Z | - |
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