Browse

Dendropanax morbifera Léveille extract ameliorates cadmium-induced impairment in memory and hippocampal neurogenesis in rats

DC Field Value Language
dc.contributor.authorKim, Woosuk-
dc.contributor.authorYim, Hee Sun-
dc.contributor.authorYoo, Dae Young-
dc.contributor.authorJung, Hyo Young-
dc.contributor.authorKim, Jong Whi-
dc.contributor.authorChoi, Jung Hoon-
dc.contributor.authorYoon, Yeo Sung-
dc.contributor.authorKim, Dae Won-
dc.contributor.authorHwang, In Koo-
dc.date.accessioned2017-02-06T05:17:36Z-
dc.date.available2017-02-06T05:17:36Z-
dc.date.issued2016-11-09-
dc.identifier.citationBMC Complementary and Alternative Medicine, 16(1):452ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100446-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
ko_KR
dc.description.abstractAbstract

Background
Cadmium leads to learning and memory impairment. Dendropanax morbifera Léveille stem extract (DMS) reduces cadmium-induced oxidative stress in the hippocampus. We investigated the effects of DMS on cadmium-induced impairments in memory in rats.


Methods
Cadmium (2 mg/kg), with or without DMS (100 mg/kg), was orally administered to 7-week-old Sprague-Dawley rats for 28 days. Galantamine (5 mg/kg), an acetylcholinesterase inhibitor, was intraperitoneally administered as a positive control. A novel-object recognition test was conducted 2 h after the final administration. Cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin, respectively. Acetylcholinesterase activity in the synaptosomes of the hippocampus was also measured based on the formation of 5,5′-dithio-bis-acid nitrobenzoic acid.


Results
An increase in the preferential exploration time of new objects was observed in both vehicle-treated and cadmium-treated rats. In addition, DMS administration increased cell proliferation and neuroblast differentiation in the dentate gyrus of vehicle-treated and cadmium-treated rats. Acetylcholinesterase activity in the hippocampal synaptosomes was also significantly higher in the DMS-treated group than in the vehicle-treated group. The effect of DMS on cadmium-induced memory impairment and cell proliferation in the hippocampus was comparable to that of galantamine.


Conclusions
These results suggest that DMS ameliorates cadmium-induced memory impairment via increase in cell proliferation, neuroblast differentiation, and acetylcholinesterase activity in the hippocampus. The consumption of DMS may reduce cadmium-induced neurotoxicity in animals or humans.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectDendropanax morbifera extractko_KR
dc.subjectCadmiumko_KR
dc.subjectNeurogenesisko_KR
dc.subjectMemoryko_KR
dc.subjectAcetylcholinesteraseko_KR
dc.titleDendropanax morbifera Léveille extract ameliorates cadmium-induced impairment in memory and hippocampal neurogenesis in ratsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김우석-
dc.contributor.AlternativeAuthor임희선-
dc.contributor.AlternativeAuthor유대영-
dc.contributor.AlternativeAuthor정효영-
dc.contributor.AlternativeAuthor김종휘-
dc.contributor.AlternativeAuthor최정훈-
dc.contributor.AlternativeAuthor윤여성-
dc.contributor.AlternativeAuthor김대원-
dc.contributor.AlternativeAuthor황인구-
dc.identifier.doi10.1186/s12906-016-1435-z-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2017-01-06T10:01:40Z-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse