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A genome-wide scan for signatures of directional selection in domesticated pigs

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dc.contributor.authorMoon, Sunjin-
dc.contributor.authorKim, Tae-Hun-
dc.contributor.authorLee, Kyung-Tai-
dc.contributor.authorKwak, Woori-
dc.contributor.authorLee, Taeheon-
dc.contributor.authorLee, Si-Woo-
dc.contributor.authorKim, Myung-Jick-
dc.contributor.authorCho, Kyuho-
dc.contributor.authorKim, Namshin-
dc.contributor.authorChung, Won-Hyong-
dc.contributor.authorSung, Samsun-
dc.contributor.authorPark, Taesung-
dc.contributor.authorCho, Seoae-
dc.contributor.authorGroenen, Martien AM-
dc.contributor.authorNielsen, Rasmus-
dc.contributor.authorKim, Yuseob-
dc.contributor.authorKim, Heebal-
dc.date.accessioned2017-02-07T01:42:57Z-
dc.date.available2017-02-07T01:42:57Z-
dc.date.issued2015-02-25-
dc.identifier.citationBMC Genomics, 16(1):130ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100472-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
ko_KR
dc.description.abstractBackground
Animal domestication involved drastic phenotypic changes driven by strong artificial selection and also resulted in new populations of breeds, established by humans. This study aims to identify genes that show evidence of recent artificial selection during pig domestication.

Results
Whole-genome resequencing of 30 individual pigs from domesticated breeds, Landrace and Yorkshire, and 10 Asian wild boars at ~16-fold coverage was performed resulting in over 4.3 million SNPs for 19,990 genes. We constructed a comprehensive genome map of directional selection by detecting selective sweeps using an F
ST-based approach that detects directional selection in lineages leading to the domesticated breeds and using a haplotype-based test that detects ongoing selective sweeps within the breeds. We show that candidate genes under selection are significantly enriched for loci implicated in quantitative traits important to pig reproduction and production. The candidate gene with the strongest signals of directional selection belongs to group III of the metabolomics glutamate receptors, known to affect brain functions associated with eating behavior, suggesting that loci under strong selection include loci involved in behaviorial traits in domesticated pigs including tameness.

Conclusions
We show that a significant proportion of selection signatures coincide with loci that were previously inferred to affect phenotypic variation in pigs. We further identify functional enrichment related to behavior, such as signal transduction and neuronal activities, for those targets of selection during domestication in pigs.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectPigko_KR
dc.subjectDomesticationko_KR
dc.subjectSelective sweepko_KR
dc.subjectDirectional selectionko_KR
dc.subjectQuantitative traitsko_KR
dc.titleA genome-wide scan for signatures of directional selection in domesticated pigsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor문선진-
dc.contributor.AlternativeAuthor김태훈-
dc.contributor.AlternativeAuthor이경태-
dc.contributor.AlternativeAuthor곽우리-
dc.contributor.AlternativeAuthor이태헌-
dc.contributor.AlternativeAuthor이시우-
dc.contributor.AlternativeAuthor김명직-
dc.contributor.AlternativeAuthor조규호-
dc.contributor.AlternativeAuthor김남신-
dc.contributor.AlternativeAuthor정원형-
dc.contributor.AlternativeAuthor성삼선-
dc.contributor.AlternativeAuthor박태성-
dc.contributor.AlternativeAuthor조서애-
dc.contributor.AlternativeAuthor김유섭-
dc.contributor.AlternativeAuthor김희발-
dc.identifier.doi10.1186/s12864-015-1330-x-
dc.language.rfc3066en-
dc.rights.holderMoon et al.; licensee BioMed Central.-
dc.date.updated2017-01-06T10:05:37Z-
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Program in Agricultural Biotechnology (협동과정-농업생물공학전공)Journal Papers (저널논문_협동과정-농업생물공학전공)
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