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Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

Cited 46 time in Web of Science Cited 44 time in Scopus
Authors
Choi, Yoon-La; Oh, Ensel; Park, Sarah; Kim, Yeonju; Park, Yeon-Hee; Song, Kyoung; Cho, Eun Yoon; Hong, Yun-Chul; Choi, Jong Sun; Lee, Jeong Eon; Kim, Jung Han; Nam, Seok Jin; Im, Young-Hyuck; Yang, Jung-Hyun; Shin, Young Kee
Issue Date
2010-09-23
Publisher
BioMed Central
Citation
BMC Cancer, 10(1):507
Description
This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Abstract
Abstract

Background
Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs).


Methods
Using tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR).


Results
The results of this study showed that both TNBCs and BLBCs were associated with high histological and/or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6~8% of breast cancers in publicly available breast cancer datasets


Conclusion
The QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of subgroups of patients for therapeutic classification.
Language
English
URI
https://hdl.handle.net/10371/100508
DOI
https://doi.org/10.1186/1471-2407-10-507
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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