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IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Oh, Keunhee | - |
dc.contributor.author | Lee, Ok-Young | - |
dc.contributor.author | Park, Yeonju | - |
dc.contributor.author | Seo, Myung Won | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.date.accessioned | 2017-02-08T02:27:53Z | - |
dc.date.available | 2017-02-08T02:27:53Z | - |
dc.date.issued | 2016-09-08 | - |
dc.identifier.citation | BMC Cancer, 16(1):724 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100531 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background We previously reported that IL-6 and transglutaminase 2 (TG2) were expressed in more aggressive basal-like breast cancer cells, and TG2 and IL-6 expression gave these cells stem-cell-like phenotypes, increased invasive ability, and increased metastatic potential. In the present study, the underlying mechanism by which IL-6 production is induced in luminal-type breast cancer cells was evaluated, and TG2 overexpression, IL-1β stimulation, and IL-6 expression were found to give cancerous cells a hormone-independent phenotype. Methods Luminal-type breast cancer cells (MCF7 cells) were stably transfected with TG2. To evaluate the requirement for IL-6 neogenesis, MCF7 cells were stimulated with various cytokines. To evaluate tumorigenesis, cancer cells were grown in a three-dimensional culture system and grafted into the mammary fat pads of NOD/scid/IL-2Rγ−/− mice. Results IL-1β induced IL-6 production in TG2-expressing MCF7 cells through an NF-kB-, PI3K-, and JNK-dependent mechanism. IL-1β increased stem-cell-like phenotypes, invasiveness, survival in a three-dimensional culture model, and estrogen-independent tumor growth of TG2-expressing MCF7 cells, which was attenuated by either anti-IL-6 or anti-IL-1β antibody treatment. Conclusion Within the inflammatory tumor microenvironment, IL-1β increases luminal-type breast cancer cell aggressiveness by stimulating IL-6 production through a TG2-dependent mechanism. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Luminal-type breast cancer cell | ko_KR |
dc.subject | Hormone-independent | ko_KR |
dc.subject | IL-1β | ko_KR |
dc.subject | IL-6 | ko_KR |
dc.subject | Transglutaminase 2 | ko_KR |
dc.title | IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 오근희 | - |
dc.contributor.AlternativeAuthor | 이옥영 | - |
dc.contributor.AlternativeAuthor | 박연주 | - |
dc.contributor.AlternativeAuthor | 서명원 | - |
dc.contributor.AlternativeAuthor | 이동섭 | - |
dc.identifier.doi | 10.1186/s12885-016-2746-7 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-01-06T10:15:10Z | - |
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