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Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study
DC Field | Value | Language |
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dc.contributor.author | Kim, Ryul | - |
dc.contributor.author | Ock, Chan-Young | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Paeng, Jin Chul | - |
dc.contributor.author | Kwon, Seong Keun | - |
dc.contributor.author | Hah, J. Hun | - |
dc.contributor.author | Kwon, Tack-Kyun | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2017-02-08T02:31:08Z | - |
dc.date.available | 2017-02-08T02:31:08Z | - |
dc.date.created | 2018-08-23 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | BMC Cancer, Vol.16, p. 116 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.other | 46268 | - |
dc.identifier.uri | https://hdl.handle.net/10371/100532 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Background: The accuracy of F-18 fluorodeoxygluocose positron emission tomography/computed tomography (PET/CT) in predicting immediate failure after radical chemoradiotherapy (CRT) for HNSCC is poorly characterized at present. The purpose of this study was to examine PET/CT as a predictive and prognostic gauge of immediate failure after CRT and determine the impact of these studies on clinical decision making in terms of salvage surgery. Methods: Medical records of 78 consecutive patients receiving radical CRT for locally advanced HNSCC were reviewed, analyzing PET/CTs done before and 3 months after CRT. Immediate failure was defined as residual disease or locoregional and/or systemic relapse within 6 months after CRT. Results: Maximum standard uptake value (SUV) of post CRT PET/CT (postSUVmax) was found optimal for predicting immediate failure at a cutpoint of 4.4. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were 90.0 %, 83.8 %, 98.3 %, and 45.0 %, respectively. Of 78 patients studied, postSUVmax >= 4.4 prevailed in 20 (25.6 %), with postSUVmax < 4.4 in 58 (74.4 %). At postSUVmax >= 4.4 (vs. postSUVmax < 4.4) OS was poorer by comparison (3-year OS: 56.9 vs. 87.7 %; P = 0.005), as was progression-free survival (3-year PFS: 42.9 vs. 81.1 %; P < 0.001). At postSUVmax >= 4.4, OS with and without immediate salvage surgery did not differ significantly (3-year OS: 60.0 vs. 55.6 %; Log-rank P = 0.913). Conclusion: Post CRT PET/CT imaging has prognostic value in terms of OS and PFS and is useful in predicting immediate therapeutic failure, given its high NPV. However, OS was not significantly altered by early salvage surgery done on the basis of post CRT PET/CT findings. | - |
dc.language | 영어 | - |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | - |
dc.title | Predictive and prognostic value of PET/CT imaging post-chemoradiotherapy and clinical decision-making consequences in locally advanced head & neck squamous cell carcinoma: a retrospective study | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 권택균 | - |
dc.contributor.AlternativeAuthor | 하정훈 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.identifier.doi | 10.1186/s12885-016-2147-y | - |
dc.citation.journaltitle | BMC Cancer | - |
dc.identifier.wosid | 000370228800005 | - |
dc.identifier.scopusid | 2-s2.0-84957938119 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Kim et al. | - |
dc.date.updated | 2017-01-06T10:13:07Z | - |
dc.citation.startpage | 116 | - |
dc.citation.volume | 16 | - |
dc.identifier.sci | 000370228800005 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hah, J. Hun | - |
dc.contributor.affiliatedAuthor | Kwon, Tack-Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Sung, Myung-Whun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | FDG-PET | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | SALVAGE SURGERY | - |
dc.subject.keywordPlus | TUMOR RESPONSE | - |
dc.subject.keywordPlus | CONCURRENT CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | INDUCTION CHEMOTHERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordAuthor | Head and neck cancer | - |
dc.subject.keywordAuthor | PET/CT | - |
dc.subject.keywordAuthor | Salvage surgery | - |
dc.subject.keywordAuthor | Concurrent chemoradiotherapy | - |
dc.subject.keywordAuthor | Survival | - |
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