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Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimers disease cybrid cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Jin-Heon | - |
dc.contributor.author | Yum, Kyu Sun | - |
dc.contributor.author | Chang, Jun Young | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Ahn, Jin-young | - |
dc.contributor.author | Kim, SangYun | - |
dc.contributor.author | Lapchak, Paul A | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.date.accessioned | 2017-02-08T05:45:27Z | - |
dc.date.available | 2017-02-08T05:45:27Z | - |
dc.date.issued | 2015-07-31 | - |
dc.identifier.citation | BMC Neurology, 15(1):127 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100552 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ko_KR |
dc.description.abstract | Abstract
Background Alzheimers disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. Methods We used mitochondrial transgenic neuronal cell (cybrid) models to investigate changes in the levels of intracellular hypoxia inducible factor 1α (HIF-1α) and β-site amyloid precursor protein cleaving enzyme (BACE) in the presence of simvastatin. Sporadic AD (SAD) and age-matched control (CTL) cybrids were exposed to 2% O2 and incubated with 1μM or 10μM simvastatin. Results There was no significant difference between cell survival by 1 or 10μM simvastatin in both SAD and CTL cybrids. In the presence of 1μM simvastatin, intracellular levels of HIF-1α and BACE decreased by 40–70% in SAD, but not CTL cybrids. However, 10μM simvastatin increased HIF-1α and BACE expression in both cybrid models. Conclusion Our results suggest demonstrate differential dose-dependent effects of simvastatin on HIF-1α and BACE in cultured Alzheimers disease cybrid cells. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Alzheimer’s disease | ko_KR |
dc.subject | Cybrid cell | ko_KR |
dc.subject | Statin | ko_KR |
dc.subject | Hypoxia | ko_KR |
dc.subject | HIF-1α | ko_KR |
dc.subject | BACE | ko_KR |
dc.title | Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimers disease cybrid cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정진헌 | - |
dc.contributor.AlternativeAuthor | 염규선 | - |
dc.contributor.AlternativeAuthor | 장준영 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 안진영 | - |
dc.contributor.AlternativeAuthor | 김상윤 | - |
dc.contributor.AlternativeAuthor | 한문구 | - |
dc.identifier.doi | 10.1186/s12883-015-0390-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Jeong et al. | - |
dc.date.updated | 2017-01-06T10:16:19Z | - |
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