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Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimers disease cybrid cells

DC Field Value Language
dc.contributor.authorJeong, Jin-Heon-
dc.contributor.authorYum, Kyu Sun-
dc.contributor.authorChang, Jun Young-
dc.contributor.authorKim, Manho-
dc.contributor.authorAhn, Jin-young-
dc.contributor.authorKim, SangYun-
dc.contributor.authorLapchak, Paul A-
dc.contributor.authorHan, Moon-Ku-
dc.date.accessioned2017-02-08T05:45:27Z-
dc.date.available2017-02-08T05:45:27Z-
dc.date.issued2015-07-31-
dc.identifier.citationBMC Neurology, 15(1):127ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100552-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly credited.
ko_KR
dc.description.abstractAbstract

Background
Alzheimers disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein.


Methods
We used mitochondrial transgenic neuronal cell (cybrid) models to investigate changes in the levels of intracellular hypoxia inducible factor 1α (HIF-1α) and β-site amyloid precursor protein cleaving enzyme (BACE) in the presence of simvastatin. Sporadic AD (SAD) and age-matched control (CTL) cybrids were exposed to 2 % O2 and incubated with 1 μM or 10 μM simvastatin.


Results
There was no significant difference between cell survival by 1 or 10 μM simvastatin in both SAD and CTL cybrids. In the presence of 1 μM simvastatin, intracellular levels of HIF-1α and BACE decreased by 40–70 % in SAD, but not CTL cybrids. However, 10 μM simvastatin increased HIF-1α and BACE expression in both cybrid models.


Conclusion
Our results suggest demonstrate differential dose-dependent effects of simvastatin on HIF-1α and BACE in cultured Alzheimers disease cybrid cells.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAlzheimer’s diseaseko_KR
dc.subjectCybrid cellko_KR
dc.subjectStatinko_KR
dc.subjectHypoxiako_KR
dc.subjectHIF-1αko_KR
dc.subjectBACEko_KR
dc.titleDose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimers disease cybrid cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor정진헌-
dc.contributor.AlternativeAuthor염규선-
dc.contributor.AlternativeAuthor장준영-
dc.contributor.AlternativeAuthor김만호-
dc.contributor.AlternativeAuthor안진영-
dc.contributor.AlternativeAuthor김상윤-
dc.contributor.AlternativeAuthor한문구-
dc.identifier.doi10.1186/s12883-015-0390-5-
dc.language.rfc3066en-
dc.rights.holderJeong et al.-
dc.date.updated2017-01-06T10:16:19Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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