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Dysnatremia, its correction, and mortality in patients undergoing continuous renal replacement therapy: a prospective observational study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Seung Seok | - |
dc.contributor.author | Bae, Eunjin | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Han, Jin Suk | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.date.accessioned | 2017-02-09T01:08:56Z | - |
dc.date.available | 2017-02-09T01:08:56Z | - |
dc.date.issued | 2016-01-05 | - |
dc.identifier.citation | BMC Nephrology, 17(1):2 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100570 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Although dysnatremia has been reported to be correlated with mortality risk, this issue remains unresolved in patients undergoing continuous renal replacement therapy (CRRT). Furthermore, it has not been determined whether change in or correction of sodium is related to mortality risk in this subset. Methods A total of 569 patients were prospectively enrolled at the start of CRRT between May 2010 and September 2013. The patients were divided into 5 groups: normonatremia (135–145mmol/L), mild hyponatremia (131.1–134.9mmol/L), moderate to severe hyponatremia (115.4–131.0mmol/L), mild hypernatremia (145.1–148.4mmol/L), and moderate to severe hypernatremia (148.5–166.0mmol/L). The non-linear relationship between sodium and mortality was initially explored. Subsequently, the odds ratios (ORs) for 30-day mortality were calculated after adjustment of multiple covariates. Results The relationship between baseline sodium and mortality was U-shaped. The mild hyponatremia, moderate to severe hyponatremia, and moderate to severe hypernatremia groups had greater ORs for mortality (1.65, 1.91, and 2.32, respectively) than the normonatremia group (all P values < 0.05). However, later sodium levels (24 and 72h after CRRT) did not predict 30-day mortality. Furthermore, the changes in sodium over 24 or 72h, including the appropriate correction of dysnatremia, did not show any relationships with mortality, irrespective of baseline sodium level. Conclusions Sodium level at the start of CRRT was a strong predictor of mortality. However, changes in sodium level and the degree of sodium correction were not associated with the mortality risk in the patients with CRRT. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Continuous renal replacement therapy | ko_KR |
dc.subject | Dysnatremia | ko_KR |
dc.subject | Hypernatremia | ko_KR |
dc.subject | Hyponatremia | ko_KR |
dc.subject | Mortality | ko_KR |
dc.title | Dysnatremia, its correction, and mortality in patients undergoing continuous renal replacement therapy: a prospective observational study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한승석 | - |
dc.contributor.AlternativeAuthor | 배은진 | - |
dc.contributor.AlternativeAuthor | 김동기 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 한진석 | - |
dc.contributor.AlternativeAuthor | 주권욱 | - |
dc.identifier.doi | 10.1186/s12882-015-0215-1 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Han et al. | - |
dc.date.updated | 2017-01-06T10:18:39Z | - |
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