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The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

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dc.contributor.authorHong, Eun Shil-
dc.contributor.authorLim, Cheong-
dc.contributor.authorChoi, Hye Yeon-
dc.contributor.authorKu, Eu Jeong-
dc.contributor.authorKim, Kyoung Min-
dc.contributor.authorMoon, Jae Hoon-
dc.contributor.authorLim, Soo-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorJang, Hak Chul-
dc.contributor.authorChoi, Sung Hee-
dc.date.accessioned2017-02-10T01:37:25Z-
dc.date.available2017-03-16T17:48:35Z-
dc.date.issued2015-05-09-
dc.identifier.citationCardiovascular Diabetology, 14(1):50ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/100666-
dc.descriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.ko_KR
dc.description.abstractBackground
The complement component C1q triggers activation of the classical immune pathway and can bind to adiponectin (APN). Recently, some studies have been reported that serum C1q-APN/total APN ratio correlates with atherosclerosis and coronary artery disease (CAD). We assessed the relationships between C1q related variables and the severity of CAD, and investigated the localization of the C1q–APN complex.

Methods
The sample included 153 subjects comprising healthy controls and patients with subclinical or overt CAD. We measured the serum concentrations of C1q, total APN, and high-molecular weight (HMW)-APN, and the amount of C1q–APN complex. We identified the sites of C1q–APN complex deposition in various adipose tissues and blood vessels.

Results
Serum concentrations of C1q and HMW-APN and the C1q/HMW-APN ratio were independently associated with the severity of coronary stenosis. The amount of C1q–APN complex was significantly higher in patients with CAD compared with controls. C1q and APN co-localized in perivascular areas of subcutaneous, visceral, and pericardial fat tissues, and the internal mammary artery of patients with severe CAD.

Conclusions
Serum C1q concentration and the C1q/HMW-APN ratio were independent markers of coronary artery stenosis. The amount of C1q–APN complex was significantly greater in serum from CAD patients. C1q and APN co-localized to perivascular areas in adipose tissue and blood vessels. The association between the increased amount of the C1q–APN complex and CAD should be investigated further.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectC1qko_KR
dc.subjectAdiponectinko_KR
dc.subjectHigh-molecular weight adiponectinko_KR
dc.subjectCoronary artery diseaseko_KR
dc.subjectBiomarkerko_KR
dc.titleThe amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patientsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor홍은실-
dc.contributor.AlternativeAuthor임청-
dc.contributor.AlternativeAuthor최혜연-
dc.contributor.AlternativeAuthor구의정-
dc.contributor.AlternativeAuthor김경민-
dc.contributor.AlternativeAuthor문재훈-
dc.contributor.AlternativeAuthor임수-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor장학철-
dc.contributor.AlternativeAuthor최성희-
dc.identifier.doi10.1186/s12933-015-0209-0-
dc.language.rfc3066en-
dc.rights.holderHong et al.; licensee BioMed Central.-
dc.date.updated2017-01-06T10:24:39Z-
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