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Surgical outcome and prognostic factors of pediatric epilepsy caused by cortical dysplasia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, C. K. | - |
dc.contributor.author | Kim, S. K. | - |
dc.contributor.author | Wang, K. C. | - |
dc.contributor.author | Hwang, Y. S. | - |
dc.contributor.author | Kim, K. J. | - |
dc.contributor.author | Chae, J. H. | - |
dc.contributor.author | Chi, J. G. | - |
dc.contributor.author | Choe, G. Y. | - |
dc.contributor.author | Kim, N. R. | - |
dc.contributor.author | Cho, B. K. | - |
dc.date.accessioned | 2009-10-06T03:11:09Z | - |
dc.date.available | 2009-10-06T03:11:09Z | - |
dc.date.issued | 2006-03-17 | - |
dc.identifier.citation | Childs Nerv Syst 22:586-592 | en |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10187 | - |
dc.description.abstract | OBJECTS: We analyzed 30 patients with cortical dysplasia (CD) and epilepsy to evaluate the clinical characteristics and surgical outcome of both epilepsy control and neurocognition. MATERIALS AND METHODS: The mean ages at seizure onset and at the time of the operation were 3.6 years (range, 1 month-12.6 years) and 10.3 years (range, 1.5-18.3 years), respectively. The mean follow-up period was 3.2 years (range, 1-5.3 years). (18)FDG-positron emission tomography was the most sensitive and magnetic resonance imaging was the most specific in localizing the lesion. Developmental/intellectual delay was predominant in the early-onset group (n=18, seizure onset <3 years), with intelligence tending to be normal in the late-onset group (n=12, seizure onset >or=3 years). Mild CD predominated in the late-onset epilepsy group and moderate or severe CD in the early-onset group (p=0.005). The surgical success rate of epilepsy control was 87%. A better outcome was obtained if the lesion was confined to the temporal lobe. School performance was favorable in 43%. The age at seizure onset and preoperative developmental/intellectual delay were the important prognostic factors in school performance as well as the epilepsy control. A total of 77% of patients had relatively good social adaptation. Successful epilepsy control and good school performance were affirmative conditions precedent to social adaptation. CONCLUSIONS: Due to the favorable control of epilepsy and its effect on school performance and social adaptation, surgical treatment is strongly recommended for cortical dysplasia and intractable epilepsy. | en |
dc.description.sponsorship | This study was supported by a grant from the
Korea Health 21 R&D Project, the Ministry of Health and Welfare (HMP-99-N-02-0003), and BK21 Human Life Sciences, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | en |
dc.subject | Adolescent | en |
dc.subject | Brain Diseases/complications/*surgery | en |
dc.subject | Cerebral Cortex/*abnormalities/*surgery | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Electroencephalography | en |
dc.subject | Epilepsy/etiology/pathology/*surgery | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Male | en |
dc.subject | Positron-Emission Tomography | en |
dc.subject | Prognosis | en |
dc.subject | Retrospective Studies | en |
dc.subject | Tomography, Emission-Computed, Single-Photon | en |
dc.subject | Treatment Outcome | - |
dc.title | Surgical outcome and prognostic factors of pediatric epilepsy caused by cortical dysplasia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김승기 | - |
dc.contributor.AlternativeAuthor | 왕규창 | - |
dc.contributor.AlternativeAuthor | 김기중 | - |
dc.contributor.AlternativeAuthor | 채종희 | - |
dc.contributor.AlternativeAuthor | 지제근 | - |
dc.contributor.AlternativeAuthor | 최기영 | - |
dc.contributor.AlternativeAuthor | 김나래 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.identifier.doi | 10.1007/s00381-006-0085-8 | - |
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