Publications
Detailed Information
Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Me-Yeon | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Ha, Sung Whan | - |
dc.contributor.author | Kim, Jae Sung | - |
dc.contributor.author | Kim, In Ah | - |
dc.contributor.author | Lee, Hyo-Pyo | - |
dc.date.accessioned | 2009-10-14T10:19:00Z | - |
dc.date.available | 2009-10-14T10:19:00Z | - |
dc.date.issued | 2006-09-26 | - |
dc.identifier.citation | Gynecol Oncol 2007;104:95-9 | en |
dc.identifier.issn | 0090-8258 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-4KY88DW-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=77ea887a3c803f82d0a977ef668ea8f7 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16996117 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10445 | - |
dc.description.abstract | OBJECTIVES: To evaluate the toxicity and the efficacy of paclitaxel/carboplatin chemoradiotherapy as a definitive treatment for squamous cell cancer of the uterine cervix. METHODS: From March 2000 to January 2004, 33 patients with squamous cell cancer of the uterine cervix were treated with concurrent chemoradiotherapy including 2 cycles of paclitaxel (135 mg/m(2)) and carboplatin (area under the time-concentration curve 4.5 mg min/ml) at 4-week interval. Seven patients received adjuvant chemotherapy with the same chemotherapeutic regimen. All patients received external beam radiotherapy with 41.4-51.4 Gy (median 50.4 Gy) to the whole pelvis. Twenty-eight patients received boost irradiation to the cervix by brachytherapy with 25.6-43.3 Gy (median 34.6 Gy) and 5 patients by external beam radiotherapy with 10.8-14.4 Gy (median 14.4 Gy). RESULTS: A median follow-up period was 27 months (range: 6-53 months). Acute hematological toxicity of grade 3 or 4 developed in 20 patients (61%), and acute gastrointestinal toxicity of grade 3 developed in 1 patient (3%). Vesicovaginal fistula occurred in 2 patients (6%). All patients achieved objective response (CR 70%, PR 30%) in 2 months after termination of treatment. One patient had a local progression in cervix, and 4 patients developed distant metastases. The 3-year estimated disease-free survival rates for stages I-IIA, IIB, III and IV were 67%, 91%, 88% and 50%, respectively. The 3-year estimated survival rates for stages I-IIA, IIB, III and IV were 89%, 91%, 88% and 50%, respectively. CONCLUSION: Concurrent chemoradiotherapy with paclitaxel and carboplatin is effective to achieve an excellent pelvic control. | en |
dc.language.iso | en | en |
dc.publisher | Academic Press | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/adverse | en |
dc.subject | effects/*therapeutic use | en |
dc.subject | Carboplatin/administration & dosage/adverse effects | en |
dc.subject | Carcinoma, Squamous Cell/*drug therapy/pathology/*radiotherapy | en |
dc.subject | Combined Modality Therapy | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Paclitaxel/administration & dosage/adverse effects | en |
dc.subject | Retrospective Studies | en |
dc.subject | Survival Rate | en |
dc.subject | Uterine Cervical Neoplasms/*drug therapy/pathology/*radiotherapy | en |
dc.title | Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이미연 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 김규보 | - |
dc.contributor.AlternativeAuthor | 하성환 | - |
dc.contributor.AlternativeAuthor | 김재성 | - |
dc.contributor.AlternativeAuthor | 이효표 | - |
dc.identifier.doi | 10.1016/j.ygyno.2006.07.021 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.