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MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings

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dc.contributor.authorKim, E.-
dc.contributor.authorNa, D. G.-
dc.contributor.authorKim, E. Y.-
dc.contributor.authorKim, J. H.-
dc.contributor.authorSon, K. R.-
dc.contributor.authorChang, K. H.-
dc.date.accessioned2009-10-17-
dc.date.available2009-10-17-
dc.date.issued2007-
dc.identifier.citationAJNR Am J Neuroradiol 2007;28:1652-8en
dc.identifier.issn0195-6108 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17885234-
dc.identifier.urihttps://hdl.handle.net/10371/10474-
dc.description.abstractBACKGROUND AND PURPOSE: MR imaging features of metronidazole-induced encephalopathy (MIE) have not been fully established. This study was undertaken to determine the topographic distributions and diffusion-weighted imaging (DWI) findings of MIE. MATERIALS AND METHODS: We retrospectively evaluated the initial MR images (n = 7), including DWI (n = 5), and follow-up MR images (n = 4) after drug discontinuation in 7 patents with clinically diagnosed MIE. The topographic distributions of lesions were evaluated on MR images, and DWI signal intensities and apparent diffusion coefficient (ADC) values of the lesions were assessed. RESULTS: MR images demonstrated bilateral symmetric T2 hyperintense lesions in the cerebellar dentate nucleus (n = 7), midbrain (n = 7), dorsal pons (n = 6), medulla (n = 4), corpus callosum (n = 4), and cerebral white matter (n = 1). Brain stem lesions involved the following: tectum (n = 5), tegmentum (n = 4), red nucleus (n = 3) of the midbrain, vestibular nucleus (n = 6), and a focal tegmental lesion involving the superior olivary nucleus (n = 6) and abducens nucleus (n = 4) of the pons and vestibular nucleus (n = 4) and inferior olivary nucleus (n = 1) of the medulla. DWI (n = 5) showed isointensity or hyperintensity of lesions, and the decreased ADC value was found only in the corpus callosum lesions (n = 2). All detected lesions were completely reversible at follow-up except for the single corpus callosum lesion with an initial low ADC value. CONCLUSION: Brain lesions were typically located at the cerebellar dentate nucleus, midbrain, dorsal pons, medulla, and splenium of the corpus callosum. According to DWI, most of the lesions in MIE probably corresponded to areas of vasogenic edema, whereas only some of them, located in the corpus callosum, corresponded to cytotoxic edema.en
dc.language.isoenen
dc.publisherAmerican Society of Neuroradiologyen
dc.subjectAgeden
dc.subjectAnti-Infective Agents/adverse effectsen
dc.subjectBrain/*drug effects/*pathologyen
dc.subjectBrain Diseases/*chemically induced/*pathologyen
dc.subjectDiffusion Magnetic Resonance Imaging/*methodsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisted/*methodsen
dc.subjectMaleen
dc.subjectMetronidazole/*adverse effectsen
dc.subjectMiddle Ageden
dc.subjectRetrospective Studiesen
dc.titleMR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findingsen
dc.typeArticleen
dc.identifier.doi10.3174/ajnr.A0655-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Radiation Applied Life Science (대학원 협동과정 방사선응용생명과학전공)Journal Papers (저널논문_방사선응용생명과학전공)
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