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The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors
Lee, Sei Won; Kim, Dal Rae; Kim, Tae Jung; Paik, Jin Ho; Chung, Jin-Haeng; Jheon, Sanghoon; Huh, Jin Won; Lee, Jae-Ho; Lee, Choon-Taek
Issue Date
2012-11-21
Publisher
BioMed Central
Citation
Respiratory Research, 13(1):106
Keywords
SmokingEmphysemaCOPDToll-like receptor
Abstract
Background
An association between innate immunity including Toll-like receptors (TLRs) and COPD is reported recently; TLR4 deficiency in lung can cause emphysema in animals, which is not evident in humans. We analyzed the association of TLR4 expression, airflow limitation and emphysema in smokers.

Methods
We enrolled patients of ≥40years old with smoking histories of ≥10 pack-years and who had undergone lung resection. We measured TLR4 expression in lung lysates. The severity of emphysema was evaluated on computed tomography. TLR4 expression was also evaluated immunohistochemically.

Results
In total, 53 patients were enrolled. Forced expiratory volume in one second per forced vital capacity (FEV1/FVC) increased (P=0.03) and emphysema score decreased (P=0.01) as TLR4 expression increased. These were still significant, in multiple regression analysis including sex, age, tuberculosis history, smoking history and inhaled corticosteroid (ICS) usage. We also classified patients as high, intermediate, and low expressers according to TLR4 expression. Although no differences in age, gender, tuberculosis, or smoking history were observed among the groups, emphysema severity increased significantly (P = 0.02) and FEV1/FVC decreased significantly (P = 0.006) in TLR4 low expresser. The difference in TLR4 expression based on immunohistochemistry was most prominent in bronchial and alveolar epithelial cells.

Conclusion
Down-regulated TLR4 expression in lung was associated with emphysema and airflow limitation in smokers.
Language
English
URI
https://hdl.handle.net/10371/109790
DOI
https://doi.org/10.1186/1465-9921-13-106
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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