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Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells

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dc.contributor.authorRa, Jeong Chan-
dc.contributor.authorKang, Sung Keun-
dc.contributor.authorShin, Il Seob-
dc.contributor.authorPark, Hyeong Geun-
dc.contributor.authorJoo, Sang Aun-
dc.contributor.authorKim, Jeong Geun-
dc.contributor.authorKang, Byeong-Cheol-
dc.contributor.authorLee, Yong Soon-
dc.contributor.authorNakama, Ken-
dc.contributor.authorPiao, Min-
dc.contributor.authorSohl, Bertram-
dc.contributor.authorKurtz, Andras-
dc.date.accessioned2017-03-17T06:13:45Z-
dc.date.available2017-03-17T17:13:16Z-
dc.date.issued2011-10-21-
dc.identifier.citationJournal of Translational Medicine, 9(1):181ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/109794-
dc.description.abstractProlonged life expectancy, life style and environmental changes have caused a changing disease pattern in developed countries towards an increase of degenerative and autoimmune diseases. Stem cells have become a promising tool for their treatment by promoting tissue repair and protection from immune-attack associated damage. Patient-derived autologous stem cells present a safe option for this treatment since these will not induce immune rejection and thus multiple treatments are possible without any risk for allogenic sensitization, which may arise from allogenic stem cell transplantations. Here we report the outcome of treatments with culture expanded human adipose-derived mesenchymal stem cells (hAdMSCs) of 10 patients with autoimmune associated tissue damage and exhausted therapeutic options, including autoimmune hearing loss, multiple sclerosis, polymyotitis, atopic dermatitis and rheumatoid arthritis. For treatment, we developed a standardized culture-expansion protocol for hAdMSCs from minimal amounts of fat tissue, providing sufficient number of cells for repetitive injections. High expansion efficiencies were routinely achieved from autoimmune patients and from elderly donors without measurable loss in safety profile, genetic stability, vitality and differentiation potency, migration and homing characteristics. Although the conclusions that can be drawn from the compassionate use treatments in terms of therapeutic efficacy are only preliminary, the data provide convincing evidence for safety and therapeutic properties of systemically administered AdMSC in human patients with no other treatment options. The authors believe that ex-vivo-expanded autologous AdMSCs provide a promising alternative for treating autoimmune diseases. Further clinical studies are needed that take into account the results obtained from case studies as those presented here.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectAutologous adipose mesenchymal stem cellsko_KR
dc.subjectautoimmune diseasesko_KR
dc.subjectsystemic stem cell infusionko_KR
dc.titleStem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor라정찬-
dc.contributor.AlternativeAuthor강성근-
dc.contributor.AlternativeAuthor신일섭-
dc.contributor.AlternativeAuthor박형근-
dc.contributor.AlternativeAuthor주상은-
dc.contributor.AlternativeAuthor김정근-
dc.contributor.AlternativeAuthor강병철-
dc.contributor.AlternativeAuthor이용순-
dc.identifier.doi10.1186/1479-5876-9-181-
dc.language.rfc3066en-
dc.rights.holderRa et al; licensee BioMed Central Ltd.-
dc.date.updated2017-01-06T10:32:09Z-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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